遗传对儿童精神健康发育影响的双生子研究  

A Twin Study about Genetic Effects on Mental Health Development of Children

作　　者：覃青[1] 傅一笑[1] 蒙华庆[1] 李涛[2] 罗庆华[1] 欧颖[1] 陈品红[1] 杜莲[1] 邱海棠[1] 高玉峰[1] 郑玉萍[1] 邱田[1] 

机构地区：[1]重庆医科大学附属第一医院心理卫生中心,重庆400016 [2]四川大学华西医院心理卫生中心,成都610041

出　　处：《中国循证医学杂志》2010年第3期311-315,共5页Chinese Journal of Evidence-based Medicine

基　　金：国家自然科学基金资助项目(项目编号:30470625)

摘　　要：目的了解遗传因素对儿童双生子精神健康发育的影响。方法通过教委和学校募集6～16岁在同一家庭中抚养并就读于同一所学校的双生子。签署知情同意书后,用发育和健康状况评定量表(Development and Well-Bing Assessment,DAWBA)中文版向双生子父母调查双生子的精神健康发育状况。同时采集双生子的颊粘膜标本提取DNA进行卵型鉴定。结果共募集到双生子102对,完成问卷调查93对,其中同卵双生子(MZ)50对,异卵双生子(DZ)43对。在DAWBA的情绪、行为症状及其症状产生的影响部分,计算机诊断结果显示情绪障碍中的分离性焦虑(MZ组相关系数(r)=0.821,P<0.01;DZ组r=0.348,P<0.01)、广泛性焦虑(MZ组r=0.546,P<0.01;DZ组r=0.309,P<0.01)、特殊恐怖症状(MZ组r=0.849,P<0.01;DZ组r=0.726,P<0.01)及对立/品行障碍(MZ组r=0.237,P<0.01;DZ组r=0.163,P<0.01)、注意力缺陷-多动障碍(MZ组r=0.640,P<0.01;DZ组r=0.198,P<0.01),孤独症症状(MZ组r=0.680,P<0.01;DZ组r=0.372,P<0.01),MZ组r大于DZ组。结论在影响儿童双生子精神健康发育的因素中,遗传因素起重要作用。Objective To investigate the impact of genetic factors on mental health status in child and adolescent twins. Methods A total of 102 pairs of twins aged 6 to 16 years were recruited with the support from educational committees and schools. After the guardians of these twins had signed an informed consent form, the Chinese version growth and the state of health evaluation （Development and Well-Bing Assessment, DAWBA） were completed by the parents of these twins to investigate their mental health status. Buccal mucosa samples were collected from all twins for DNA extraction and zygosity identification test. Result A total of 102 pairs of twins were recruited, among whom 93 pairs finished the investigation, including 50 monozygotic pairs and 43 dizygotic pairs. The results of emotional symptoms and behavior symptoms and the impact of symptoms from the DAWBA screening questionnaire showed that the intrapair correlation coeficien of the emotional disorder and the oppositional/conduct disorder and the impact in monozygotic twins were more remarkable than those in dizygotie twins, including separation anxiety （MZ group correlation coefficient （r） = 0.821, P0.01; DZ group r=0.348, P0.01）, generalized anxiety （MZ group r=0.546, P0.01; DZ group r=0.309, P0.01）, a special terror symptoms （MZ group r=0.849, P0.01; DZ group r=0.726, P0.01 ）, and oppositional defiant / conduct disorder （MZ group r=0.237, P0.01; DZ group r=0.163, P0.01）, attention deficit - hyperactivity disorder （MZ group r=0.640, P0.01; DZ group r=0.198, P0.01）, autistic symptoms （MZ group r=0.680, P0.01; DZ group r=0.372, P0.01）. Conclusion Genetic factors play an important role in mental health status of child twins.

关 键 词：双生子 精神健康 遗传 发育和健康状况评定(DAWBA) 

分 类 号：R749.94[医药卫生—神经病学与精神病学]