环境暴露、N-乙酰基转移酶-2基因多态性与大肠癌的关系  

Relationship between environmental exposures,genetic polymorphism of NAT2 and colorectal cancer

作　　者：彭仙娥[1] 江荧荧[1] 李林[2] 黄之敏 胡志坚[1] 史习舜[1] 

机构地区：[1]福建医科大学公共卫生学院流行病与统计学教研室,福州350004 [2]福建省肿瘤医院胸外科 [3]武警福建省边防总队海警第一支队卫生队

出　　处：《肿瘤研究与临床》2010年第2期89-91,共3页Cancer Research and Clinic

基　　金：福建省教育厅科技基金（JA05255）;福建医科大学公共卫生学院“环境与健康”重点学科发展基金（GW05）

摘　　要：目的探讨N-乙酰基转移酶-2（NAT2）基因多态性及环境暴露与大肠癌易感性的关系。方法以病例对照研究方法，采用聚合酶链反应一限制性片段长度多态性（PCR—RFLP）基因分型技术，对86对大肠癌患者和非肿瘤患者（对照组）NAT2基因型进行测定。结果NAT2慢速基因型在病例组的频率为19．58％（56例），对照组为10．14％（29例），差异具有统计学意义（χ2=10．07，P=0．00）。携带NAT2慢速基因型的个体患大肠癌的风险（OR）是携带快速基因型个体的2．16倍（95％ CI：1．31～3．54）。结论NAT2基因多态性与大肠癌的易感性有关，携带慢速基因型的人群患大肠癌的风险增加。Objective To explore the relationship between NAT2 genetic polymorphism and the risk of colorectal cancer. Methods A hospital-based case-control study was conducted and polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） method was used to detect its genotypes. Results The frequency of NAT2 slow genotype was 19.58 % in cases with colorectal cancer compared with 10.14 % in controls. As compared with the NAT2 rapid genotypes, the NAT2 slow genotype significantly increased the risk for developing eolorectal cancer and their OR were 2.16 （95 % CI： 1.31-3.54）. Conclusion The results suggest that NAT2 genetic polymorphism is associated with eolorectal cancer susceptibility. People with NAT2 slow genotype have higher eolorectal cancer risk.

关 键 词：肠肿瘤 乙酰基转移酶类 基因多态性 疾病遗传易感性 环境暴露 

分 类 号：R735.34[医药卫生—肿瘤]