重组人肝细胞生长因子抗四氯化碳染毒小鼠肝的保护效应  

RECOMBINANT HUMAN HEPATOCYTE GROWTH FACTOR PROTECTS AGAINST ACUTE LIVER FAILURE INDUCED BY CCl 4 POISONING IN MICE

作　　者：宫德正[1] 邹原[1] 梅懋华[1] 

机构地区：[1]大连医科大学生理教研室

出　　处：《中国应用生理学杂志》1998年第4期339-342,共4页Chinese Journal of Applied Physiology

基　　金：国家自然科学基金;辽宁省卫生厅科研基金

摘　　要：为检测重组人肝细胞生长因子（ｒ－ｈＨＧＦ）的保肝作用，本工作观察到ｒ－ｈＨＧＦ降低ＣＣｌ４染毒小鼠血清ＡＬＴ和ＡＳＴ升高的幅度，减轻肝组织受损的程度和防止肝细胞器的破坏，而且，ｒ－ｈＨＧＦ的这种保肝效应所需剂量极小，为ｎｇ级。根据上述资料推测。To assess the protective effect of recombinant human hepatocyte growth factor ( r hHGF ) on liver, it was found the factor was capable of suppressing elevation of serum alanine transaminase and aspartate transaminase, lessning the severity of the hepatic lession and preventing destruction of the structure of organelle in hepatocyte of mice intoxicated by carbon tetrachloride. The protective action of the r hHGF appears to be a very small dose(ng). Based upon the above mentioned data, it is suggested that r hHGF is a very effective growth factor to protect mice liver against CCL 4 injury.

关 键 词：四氯化碳 保护作用 γ-hHGF 肝 

分 类 号：R575[医药卫生—消化系统]