桂花(晚银桂、窈窕淑女和贵妃红)α-葡萄糖苷酶抑制活性  

α-glucosidase inhibitory activity of Osmanthus fragrans Lour. (Wanyingui,Yaotiaoshunv and Guifeihong)

作　　者：曹乃锋[1] 李元元 崔维恒[1] 许启泰[1] 康文艺[1] 

机构地区：[1]河南大学药学院天然药物研究所,河南开封475004 [2]河南省医药学校,河南开封475001

出　　处：《河南大学学报（医学版）》2010年第1期21-23,共3页Journal of Henan University:Medical Science

基　　金：河南省教育厅青年骨干教师资助计划(2008-755)

摘　　要：目的:对3个品种(桂花贵妃红、晚银桂和窈窕淑女)的桂花叶和花石油醚提取物α-葡萄糖苷酶抑制作用进行研究。方法:采用索氏提取法提取桂花的叶和花提取物,以96微孔板法测定α-葡萄糖苷酶抑制作用。结果:3种桂花的叶和花均有较好的α-葡萄糖苷酶抑制作用,其中以贵妃红叶提取物的活性最好(IC50=68.26 mg/L),其次为晚银桂叶和窈窕淑女叶部分提取物(IC50=145.25 mg/L和145.08 mg/L),远低于阳性对照Acarbose(IC50=1081.27 mg/L)。结论:3个品种的叶和花部分提取物对α-葡萄糖苷酶活性的抑制效果均很好。Objective： To investigate α-glucosidase inhibitory activity of three species Guifeihong,Wanyingui and Yaotiaoshunv Osmanthus fragrans Lour.petroleum ether extracts.Methods： The different extracts were extracted by Soxhlet,and α-glucosidase inhibitory activity was screened by the 96-microplate-based method.Results： The leaves and flowers of three species O.fragrans showed good inhibitory activity.The petroleum ether extract of Guifeihong had the highest inhibitor activity（IC50=68.26 mg/L）,and followed by Wanyingui（IC50=145.25 mg/L） and Yaotiaoshunv（IC50=145.08 mg/L）,which is more lower than that of Acarbose（IC50=1081.27 mg/L）.Conclusion： All extracts from Osmanthus fragrans Lour.have good inhibitory activity of α-glucosidase.

关 键 词：桂花 Α-葡萄糖苷酶 抑制活性 

分 类 号：R284.1[医药卫生—中药学]