孕妇心脏安全性评估新指标的研究  

New indices for evaluating the cardiac safety during pregnancy and data analysis

作　　者：柯明[1] 郭兴明[1] 肖守中[1,2] 

机构地区：[1]重庆大学生物工程学院,重庆400030 [2]重庆博精医学信息研究所,重庆400030

出　　处：《中国实用妇科与产科杂志》2010年第2期135-136,共2页Chinese Journal of Practical Gynecology and Obstetrics

基　　金：国家自然科学基金项目(30770551);重庆市科技攻关计划项目(CSCJ2008AC5103)

摘　　要：目的探索孕期妇女心脏安全性评估的新指标及心脏储备的变化。方法2008年于重庆大学生物工程学院,84名孕妇和71名非孕妇志愿受试者纳入研究。根据心脏储备的无创性监测方法,测量、计算和分析孕妇与非孕妇的心率、第1与第2心音幅值之比(S1/S2)、舒张期与收缩期的时限之比(D/S)。结果研究组孕妇的心率[(95.24±12.80)/min]与S1/S2(2.14±0.83)均比对照组妇女[(75.97±9.78)/min、1.84±0.86]升高,差异均有统计学意义(P<0.05);但研究组D/S(1.24±0.21)比对照组(1.57±0.32)降低,差异有统计学意义(P<0.05)。结论孕妇在妊娠这一应激过程中动用了心脏储备,导致心脏负担加重。上述新指标的研究将有益于孕期妇女心脏安全性的评估。Objective To explore new indices for evaluating the safety of the heart and the change of cardiac reserve during pregnancy.Methods Eighty-four pregnant women and seventy-one non-pregnant women volunteers participated in this study.By using a non-invasive method for measuring and evaluating cardiac reserve,the heart rate（HR）,the ratio of the first heart sound＇s amplitude to the second heart sound＇s（S1/S2）,and the ratio of diastolic duration to the systolic duration（D/S）were measured,calculated,and analyzed.Results HR [（95.24±12.80）/min] and S1/S2（2.14±0.83）of pregnant women rose as compared with the non-pregnant women＇s [（75.97±9.78）/min,1.84±0.86];The D/S（1.24±0.21）of pregnant women reduced as compared with the non-pregnant women＇s（1.57±0.32）.There are significant differences（P0.05）.Conclusion The cardiac function of pregnant women up-regulates and the cardiac burden is increased because of pregnancy stress.The research on these new indices for evaluating the safety of the heart will be beneficial to women＇s cardiac health during pregnancy.

关 键 词：心脏安全性 妊娠 心脏储备 孕妇 

分 类 号：R155[医药卫生—营养与食品卫生学]