Preventive effect of estrogen on depression-like behavior induced by chronic restraint stress  

雌激素在慢性束缚应激性抑郁发生中的作用(英文)

作　　者：厉蔚[1] 李庆娇[1] 安书成[1] 

机构地区：[1]陕西师范大学生命科学学院,脑与行为科学研究所,西安710062

出　　处：《Neuroscience Bulletin》2010年第2期140-146,共7页神经科学通报（英文版）

基　　金：supported by the Natural Science Foundation of Shaanxi Province, China (No.2006C240)

摘　　要：Objective To investigate the roles of estrogen and kalirin-7 in chronic restraint stress （CRS）-induced depression and the pathophysiological mechanism of depression. Methods Healthy female mice from Institute of Cancer Research （ICR） were randomly divided into 3 groups： control group, CRS group, and estrogen ＋ CRS group. CRS was used to establish the animal model of depression. Forced swimming test and immunohistochemistry method were utilized to investigate the animal behavior and kalirin-7 expression in the hippocampus, respectively. Results Compared with the control group, the CRS mice displayed depression-like behaviors, including a significant reduction in body weight, a significant increase in immobility time in forced swimming test, and a dramatic decrease in kalirin-7 expression in the hippocampus. However, administration of estrogen attenuated the CRS-induced negative behaviors, and simultaneously increased kalirin-7 expression. Conclusion Estrogen replacement therapy （ERT） could prevent CRS-induced depression-like behaviors in female ICR mice. Besides, kalirin-7 also plays a role in preventing CRS-induced depression-like behaviors.目的探讨雌激素和kalirin-7在慢性束缚应激性抑郁发生中的作用。方法采用慢性束缚应激性抑郁动物模型,运用强迫游泳测试和免疫组织化学方法,分别检测动物行为学表现及海马中kalirin-7蛋白的表达。结果慢性束缚应激能显著降低动物体重、延长游泳不动时间、抑制海马中kalirin-7蛋白的表达。注射雌激素能明显改善动物抑郁样行为,并且海马kalirin-7表达显著增加。结论慢性束缚应激能诱发产生抑郁样行为,而雌激素替代疗法则能预防慢性束缚应激性抑郁的发生。此外,kalirin-7在防止慢性束缚应激性抑郁的发生中起到重要作用。

关 键 词：chronic restraint stress DEPRESSION ESTROGEN neural plasticity kalirin-7 

分 类 号：R749.4[医药卫生—神经病学与精神病学]