海带多糖干预对慢性电离辐射损伤后雄性大鼠生殖功能的影响  

Effect of Laminaria japonica Polysaccharides on Reproductive Function of Male Rats with Chronic Ionizing Radiation Damage

作　　者：刘军[1,2] 罗琼[1] 杨明亮[1] 崔晓燕[1] 阎俊[1] 

机构地区：[1]武汉大学公共卫生学院,湖北武汉430071 [2]新疆大学生命科学与技术学院,新疆乌鲁木齐830046

出　　处：《食品科学》2010年第7期293-296,共4页Food Science

基　　金：达能膳食营养与宣教基金项目(DIC2007-06)

摘　　要：目的:探讨海带多糖(LJP)干预对受到慢性局部电离辐射损伤的雄性大鼠生殖功能的影响。方法:将Wistar雄性大鼠随机分为对照组、模型组和LJP组;LJP组给予LJP,其余各组以等量生理盐水灌胃;除对照组外,各组在适应性饲养7d后进行60Coγ射线局部照射,每周5次,4周20次,总剂量2.3Gy/只。分别于停止照射后第1、7、14天观察其交配能力;处死大鼠,测定其体质量与睾丸脏器系数、血清性激素(LH、FSH、T、E2)水平、精子数量及其存活率。结果:LJP组与模型组比较,脏器系数提高,性激素分泌水平得到改善,精子数量及其存活率提高,交配能力增强。结论:LJP对慢性局部电离辐射造成大鼠生殖功能的损伤有一定保护作用,对雄性大鼠生殖功能的自然恢复具有促进作用。Objective：To investigate the effect of Laminaria japonica polysaccharide（LJP） intervention on reproductive function in male rats with local chronic ionizing radiation damage.Methods：Male Wistar rats were randomly divided into control group,model group and LJP intervention group.LJP intervention group was administered LJP and the rest groups were administered saline at same volume.Except the control group,all the other groups were subjected to adaptive feeding for 7 d before the local irradiation of 60Co γ-ray at the total dose of 2.3 Gy once per day for 4 consecutive weeks.On the 1st,7th and 14th days post-60Co γ-ray irradiation,the mating ability was observed.Body weight and testis organ coefficient,serum sex hormone（LH,FSH,T,E2） levels,sperm count and sperm viability were measured.Results：Compared with the model group,the testis organ coefficient of LJP intervention group was increased.An improved level of sex hormone secretion of rats observed in LJP intervention group.Sperm count and viability and mating ability of rats from LJP intervention group were also increased.Conclusion：LJP has an obvious protective effect on reproductive function in male rats with local chronic ionizing radiation damage and plays a vital role in promoting spontaneous recovery of reproductive function in male rats.

关 键 词：海带多糖 电离辐射 生殖功能 损伤恢复 

分 类 号：R285.5[医药卫生—中药学]