食管鳞状细胞癌组织中FAK和paxillin的表达  

Expressions of FAK and paxillin proteins in esophageal squamous cell carcinoma

作　　者：赵志华[1] 庞霞[1] 李晟磊[1] 赵阿红[1] 张红新[1] 高冬玲[1] 

机构地区：[1]郑州大学第一附属医院病理科,河南省肿瘤病理学重点实验室,郑州450052

出　　处：《广东医学》2010年第8期968-970,共3页Guangdong Medical Journal

基　　金：河南省科技发展计划项目(编号:082300453202)

摘　　要：目的探讨FAK和桩蛋白(paxillin)在食管鳞状细胞癌(ESCC)组织中的表达及其意义。方法应用免疫组化SP法检测59例ESCC、27例癌旁不典型增生组织及36例正常食管黏膜组织中FAK和paxillin的表达。结果ESCC、癌旁不典型增生组织及正常黏膜组织中FAK的阳性表达率依次降低,分别为79.7%(47/59)、59.2%(16/27)和19.4%(7/36),组间比较差异有统计学意义(P<0.05);ESCC、癌旁不典型增生组织及正常黏膜组织中paxillin的阳性表达率亦依次降低,分别为71.2%(42/59)、55.6%(15/27)和36.1%(13/36),组间比较差异有统计学意义(P<0.05);FAK和paxillin表达均与ESCC的分化程度、浸润深度和淋巴结转移密切相关(P<0.05)。ESCC组织中FAK与paxillin呈正相关关系(r=0.442,P<0.05)。结论FAK和paxillin表达与ESCC的发生、发展和转移密切相关,联合检测FAK及paxillin可望成为ESCC早期诊断和预后判断的生物学标记之一,同时也将为治疗提供了新的靶点。Objective To explore the expressions of FAK and paxillin proteins in esophageal squamous cell carci- noma （ESCC）. Methods Immunohistochemical SP method was used to detect the expressions of FAk and paxillin pro- teins in 59 specimens of ESCC tissue,27 specimens of carcinoma adjacent atypical hyperplasia epithelium and 36 speci- mens of normal esophageal epithelium. Results The expression rates of FAK protein in carcinoma, adjacent atypical hy- perplasia epithelium and normal esophageal epithelium specimens were 79.7% （47/59）, 59. 3% （ 16/27 ） and 19.4% （7/ 36）, respectively. There were significant differences among the groups（ P 〈 O. 05 ）. The expression rates of paxillin pro- tein in carcinoma, adjacent atypical hyperplasia epithelium and normal esophageal epithelium specimens were 71.2% （42/ 59）, 55.6% （ 15/27 ） and 36. 1% （ 13/36 ）, respectively. There were significant differences among the groups （ P 〈 O. 05）. The expressions of FAK and paxillin proteins were significantly correlated with the grading of tumor, infiltrative depth and lymphatic metastasis in ESCC （ P 〈 0. 05 ）. There was significant positive correlation between the expressions of FAK and paxillin proteins in ESCC tissue （r = 0. 442, P 〈 O. 05 ）. Conclusion FAK and paxillin may play important roles in the infiltration, metastasis and carcinogenesis of ESCC. Combined detection of FAK and paxillin proteins can be applied in the early diagnosis and prognosis assessment for ESCC. Furthermore, they provide new potential therapeutic targets.

关 键 词：食管 鳞状细胞癌 FAK PAXILLIN 浸润 转移 

分 类 号：R735.102[医药卫生—肿瘤]