PAXILLIN

作品数:90被引量:212H指数:10
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相关领域:医药卫生更多>>
相关作者:孟宪利王雷高冬玲张红新杜媛鲲更多>>
相关机构:武汉大学福建医科大学郑州大学新疆医科大学更多>>
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相关基金:国家自然科学基金广东省卫生厅资助课题河北省普通高等学校强势特色学科基金广东省自然科学基金更多>>
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Pin1和paxillin蛋白在肺癌组织中的表达及临床意义
《中国临床新医学》2024年第7期721-727,共7页李娜 刘存宇 何志巍 
国家自然科学基金面上项目(编号:81372137)。
目的探讨Pin1和paxillin蛋白在肺癌组织及癌旁正常肺组织中的表达差异,并分析二者与临床病理特征的相关性。方法收集2018年6月至2022年9月广州医科大学附属第二医院收治的208例原发性肺癌患者的病历资料和病理组织,采用免疫组化染色(SP...
关键词:肺癌 PIN1 PAXILLIN 预后 相关性 
NLK通过调控paxillin促进膀胱癌细胞的增殖、迁移、侵袭及上皮间质转化
《哈尔滨医药》2024年第1期1-7,共7页陆建军 余琴 陈利雄 
宁波市医学科技计划项目(2017A23)。
目的探讨Nemo样激酶(nemo-like kinase;NLK)及桩蛋白(paxillin)对膀胱癌细胞增殖、迁移、侵袭及上皮间质转化(epithelial mesenchymal transition,EMT)的作用和机制,为膀胱癌的基础研究及临床预防和治疗提供理论依据。方法生物信息学分...
关键词:膀胱癌 NLK PAXILLIN EMT 
Carcinoma-associated fibroblast-derived lysyl oxidase-rich extracellular vesicles mediate collagen crosslinking and promote epithelial-mesenchymal transition via p-FAK/ p-paxillin/YAP signaling被引量:4
《International Journal of Oral Science》2023年第3期422-436,共15页Xue Liu Jiao Li Xuesong Yang Xiaojie Li Jing Kong Dongyuan Qi Fuyin Zhang Bo Sun Yuehua Liu Tingjiao Liu 
supported by the National Natural Science Foundation of China(82073001 and 82103423);Shanghai Natural Science Foundation(23ZR1454800);Scientific Research Foundation for the Introduction of Talent in Shanghai Stomatological Hospital(SSDC-2021-RC01).
Carcinoma-associated fibroblasts(CAFs)are the main cellular components of the tumor microenvironment and promote cancer progression by modifying the extracellular matrix(ECM).The tumor-associated ECM is characterized ...
关键词:Carcinoma inhibited CROSSLINKING 
Paxillin tunes the relationship between cell-matrix and cell-cell adhesions to regulate stiffness-dependent dentinogenesis被引量:1
《Regenerative Biomaterials》2023年第1期249-260,共12页Mingru Bai Zhaowei Zhang Huiyu Chen Xiaoyu Liu Jing Xie 
supported by the National Natural Science Foundation of China[82001020 and 81771047];research funding from West China School/Hospital of Stomatology,Sichuan University[RCDWJS2021-13];China Postdoctoral Science Foundation[2019M663525];the Science and Technology Project of Sichuan Province[2021YFG0238].
Mechanical stiffness is recognized as a key physical factor and directs cell function via a mechanotransduction process,from extracellular physical cues to intracellular signaling cascades that affect transcriptional ...
关键词:mechanotransduction cell-cell contacts cell-substrate adhesions odontogenic differentiation 
结直肠癌中miR-145和桩蛋白Paxillin的表达及其临床意义
《中文科技期刊数据库(引文版)医药卫生》2022年第8期60-64,共5页舒武英 陶伦 田畅 程伟 
大理市2018年科技计划项目,编号:2018KGB04。
探讨miR-145和桩蛋白(Paxillin)在结直肠癌组织表达及临床意义。方法 采用实时定量PCR检测人结直肠癌组织中miR-145表达水平,采用蛋白免疫印迹检测结直肠癌组织中桩蛋白的表达,分析结直肠癌组织与癌旁组织中miR-145 和桩蛋白表达情况,...
关键词:结直肠癌 MIR-145 桩蛋白 
ADT-OH inhibits malignant melanoma metastasis in mice via suppressing CSE/CBS and FAK/Paxillin signaling pathway
《Acta Pharmacologica Sinica》2022年第7期1829-1842,共14页Fang-fang Cai Huang-ru Xu Shi-hui Yu Ping Li Yan-yan Lu Jia Chen Zhi-qian Bi Hui-song Sun Jian Cheng Hong-qin Zhuang Zi-chun Hua 
This study was supported by grants from the Chinese National Natural Sciences Foundation(81773099,81630092 and 82130106);Department of Science and Technology of Jiangsu Province(BK20192005);the program B for Outstanding PhD candidate of Nanjng University(202001B051).
Hydrogen sulfide(H2S)is widely recognized as the third endogenous gas signaling molecule and may play a key role in cancer biological processes.ADT-OH(5-(4-hydroxyphenyl)−3H-1,2-dithiocyclopentene-3-thione)is one of t...
关键词:MELANOMA hydrogen sulfide ADT-OH EMT tumor metastasis FAK PAXILLIN CSE/CBS 
PXN-pY^31、PXN-pY^118在小鼠角膜新生血管形成中的表达变化被引量:2
《眼科新进展》2020年第4期332-335,339,共5页曹瑾 吕旭东 
咸宁市中心医院湖北科技学院附属第一医院2016年院级项目(编号2016XYA005)。
目的探讨Paxillin(PXN)-pY31、PXN-pY118在小鼠角膜碱烧伤后角膜新生血管形成过程中的表达变化。方法取健康6~8周龄雄性C57BL6小鼠36只,均右眼建立角膜碱烧伤模型为实验组,左眼不作任何处理为对照组,观察碱烧伤后1 d、3 d、5 d、7 d、1...
关键词:角膜碱烧伤 PAXILLIN 血管内皮生长因子 角膜新生血管 
Engineered chitosan for improved 3D tissue growth through Paxillin-FAK-ERK activation被引量:3
《Regenerative Biomaterials》2020年第2期141-151,共11页Md Abdul Kafi Khudishta Aktar Mitsugu Todo Ravinder Dahiya 
supported by the Japanese Society for the Promotion of Science(JSPS)postdoctoral research fellowship for foreign researcher grant(P 12380);JSPS KAKENHI Grant Number 24•02380;Marie Curie Individual Fellowship grant(BEND,H2020-MSCA-IF-2015,704807 and EPSRC Engineering Fellowship for Growth-PRINTSKIN(EP/M002527/1)).
Scaffold engineering has attracted significant attention for three-dimensional(3D)growth,prolifer-ation and differentiation of stem cells in vitro.Currently available scaffolds suffer from issues such as poor ability ...
关键词:adhesion signaling CHITOSAN HMSC porous scaffold proliferation Cys-RGD tssue engineering 
PXN表达对肝癌细胞增殖和转移能力的影响被引量:1
《铜陵职业技术学院学报》2019年第3期23-27,共5页杨梅 王波 金雯 周胜玉 朱治文 罗雪莲 邢益祥 
安徽高校自然科学研究重点项目(KJ2017A634)
目的:探讨PXN表达对肝癌细胞增殖和转移能力的影响。方法:收集2015年1月至2018年8月铜陵市人民医院病理科提供的50例原发性肝癌组织及16例癌旁组织标本,采用免疫组化法检测PXN表达,记录肝癌组织和癌旁组织PXN蛋白表达及PXN阳性与肝癌病...
关键词:肝癌HEPG2细胞 PAXILLIN 增殖 侵袭 转移 
Cytosolic phospholipase A2α modulates cell-matrix adhesion via the FAK/paxillin pathway in hepatocellular carcinoma被引量:2
《Cancer Biology & Medicine》2019年第2期377-390,共14页Piao Guo Yuchao He Lu Chen Lisha Qi Dongming Liu Ziye Chen Manyu Xiao Liwei Chen Yi Luo Ning Zhang Hua Guo 
supported by grants from Key Project of Tianjin Natural Science Foundation (Grant No.18JCZDJC35200);NSFC-FRQS program (Grant No.81661128009);The Science & Technology Development Fund of Tianjin Education Commission for Higher Education (Grant No.2017KJ202);Scientific Research Foundation for Returned Scholars and Doctoral Program of Tianjin Medical University Cancer Institute and Hospital (Grant No.B1703)
Objective: To explore the effect of cytosolic phospholipase A2α(cPLA2α) on hepatocellular carcinoma(HCC) cell adhesion and the underlying mechanisms.Methods: Cell adhesion, detachment, and hanging-drop assays were u...
关键词:HEPATOCELLULAR carcinoma CYTOSOLIC PHOSPHOLIPASE A2α cell-matrix adhesion FAK PAXILLIN 
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