CYTOSOLIC

作品数：110被引量：250H指数：8
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相关机构：中国科学院遗传与发育生物学研究所同济大学哈尔滨医科大学南京铁道医学院更多>>
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Uncoupling of nutrient metabolism and cellular redox by cytosolic routing of the mitochondrial G-3-P dehydrogenase Gpd2 causes loss of conidiation and pathogenicity in Pyricularia oryzae
《Journal of Integrative Agriculture》2025年第2期638-654,共17页Wenqin Fang Yonghe Hong Tengsheng Zhou Yangdou Wei Lili Lin Zonghua Wang Xiaohan Zhu 
funded by the National Natural Science Foundation of China(32272513 and 31770156);the Natural Sciences and Engineering Research Council of Canada(Discovery Grant,RGPIN-2016-05356);the Canadian Foundation for Innovation(Discovery Grant,227398-2011)。
Oxidation of self-stored carbohydrates and lipids provides the energy for the rapid morphogenetic transformation during asexual and infection-related development in Pyricularia oryzae,which results in intracellular ac...
关键词：Pyricularia oryzae mitochondrial G-3-P dehydrogenase NAD+/NADH balance fungal virulence mitochondrial targeted signal 
Cyclic GMP-AMP synthase recognizes the physical features of DNA
《Acta Pharmacologica Sinica》2025年第2期264-270,共7页Ling Dong Yue-ru Hou Na Xu Xiao-qian Gao Zhen Sun Qing-kai Yang Li-na Wang 
supported by grants from the National Natural Science Foundation of China(82173072).
Cyclic GMP-AMP synthase(cGAS)is a major cytosolic DNA sensor that plays a significant role in innate immunity.Upon binding to double stranded DNA(dsDNA),cGAS utilizes GTP and ATP to synthesize the second messenger cyc...
关键词：innate immune response cytosolic DNA sensor cyclic GMP-AMP synthase STING DNA physical features 
Nitrogen inhibition of nitrogenase activity involves the modulation of cytosolic invertase in soybean nodule
《Journal of Genetics and Genomics》2024年第12期1404-1412,共9页Qinzhen Xu Xin Wang Nan Wang Suning Li Xiaolei Yao Huaqin Kuang Zhimin Qiu Danxia Ke Wenqiang Yang Yuefeng Guan 
supported by funds from the National Natural Science Foundation of China(32072083);a Guangzhou Science Grant(2024A03J0010)awarded to Y.G。
Legume symbiotic nitrogen fixation(SNF)is suppressed by inorganic nitrogen(N)in the soil.High N inhibition of nitrogenase activity is associated with the deprivation of carbon allocation and metabolism in nodules.Howe...
关键词：Cytosolic invertase GmCIN1 Nitrogen fixation Carbon metabolism Symbiotic nitrogen fixation LEGUME 
Impact of mtDNA-encoded proteins arising from cytosolic translation(mPACT)
《Science Bulletin》2024年第23期3648-3651,共4页Liang Yang Yile Huang Yingzhe Ding Zhijuan Hu Xian Sheng Zhang Ying Hua Su Xingguo Liu 
financially supported by the National Key Research and Development Program of China(2023YFE0210100);the Strategic Priority Research Program of the Chinese Academy of Sciences(CAS)(XDB0480000);the National Key Research and Development Program of China(2022YFF1002902);the National Natural Science Foundation projects of China(92254301,92357302,32025010,92157202,32241002,32261160376,31970709,32070729,32100619,32170747,32322022,32370782,32371007,32300608,32300620,32471358,and 32270377);the Key Research Program,CAS(ZDBS-ZRKJZ-TLC003,154144KYSB20200006,YSBR-075);Guangdong Province Science and Technology Program(2023B0303000023,2023B1111050005,2023A1515030231,2022A1515110493,2023B1212060050,2021A1515012513,2021B1515020096,2022A1515012616,2022A1515110951,2023B1212120009,2024A1515010782,2024B1515040020,2024A1515030120,and 2023TQ07A024);Guangzhou Science and Technology Program(202102021037,202102020827,202102080066,202206060002,and 2023A04J0414).
Mitochondria are multifunctional organelles that regulate energy homeostasis,apoptosis,cell signaling and many biosynthetic pathways.Mitochondria have their own genomes that reportedly contain 37 well-known genes,incl...
关键词：HOMEOSTASIS TEMPLATE IMPACT 
Charge-guided masking of a membrane-destabilizing peptide enables efficient endosomal escape for targeted intracellular delivery of proteins
《Acta Pharmaceutica Sinica B》2024年第10期4478-4492,共15页Yan Zhao Haolin Jiang Hang Chen Jiazhen Yu Luyao Wang Wen Zhou Juanjuan Du 
supported by supported by Beijing Municipal Science&Technology Commission(Z231100007223008,China);the National Key R&D Program of China(2017YFA0207900,China);Tsinghua University Initiative Scientific Research Program(2023Z11DSZ001,China);the Tsinghua-Peking Joint Center for Life Sciences.
Intracellular delivery of biologicals such as peptides,proteins,and nucleic acids presents a great opportunity for innovative therapeutics.However,the endosome entrapment remains a major bottleneck in the intracellula...
关键词：Endosomal escape Cytosolic delivery ANTIBODY pH responsiveness LMWP Cell-penetrating peptides Targeted delivery Electrostatic masking 
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING:the inhibitory effect of Cilostazol
《Acta Pharmacologica Sinica》2024年第9期1879-1897,共19页Zhi-hua Zheng Jiao-jiao Wang Jiu-guo Lin Wei-le Ye Jia-mi Zou Li-yin Liang Ping-lian Yang Wan-lu Qiu Yuan-yuan Li Si-jia Yang Man Zhao Qing Zhou Cheng-zhi Li Min Li Zhuo-ming Li Dong-mei Zhang Pei-qing Liu Zhi-ping Liu 
National Natural Science Foundation of China(82270500,81870324,82203304,U21A20419);Guangdong Basic and Applied Basic Research Foundation(2024B1515020113);Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y093);National Engineering and Technology Research Center for New Drug Druggability Evaluation(Seed Program of Guangdong Province,2017B090903004).
Endothelial senescence,aging-related inflammation,and mitochondrial dysfunction are prominent features of vascular aging and contribute to the development of aging-associated vascular disease.Accumulating evidence ind...
关键词：CILOSTAZOL STING endothelial cell senescence INFLAMMATION mitochondrial dysfunction atherosclerosis 
Coating tetrahedral DNA framework with endosomolytic peptides for improved stability and cytosolic delivery
《Advanced Sensor and Energy Materials》2024年第2期1-5,共5页Jinjun He Xiang Ji Zihui Xu Wei He Yan Zhao Lele Sun Lan Ma 
supported by the National Key R&D Program of China(2020YFA0908900);Universities Stable Funding Key Projects(WDZC20200821104802001);the State Key Laboratory of Chemical Oncogenomics;the Institute of Biomedical Health Technology and Engineering of Shenzhen Bay Laboratory;GuangDong Basic and Applied Basic Research Foundation(2021A1515110819).
DNA nanostructures have emerged as promising carriers for drug delivery.However,challenges such as low stability,poor cellular uptake efficiency,and vulnerability to lysosomal degradation still hinder their therapeuti...
关键词：Tetrahedral DNA framework Endosomolytic peptides STABILITY Endosomal escape Efficient delivery 
The cytosolic isoform of triosephosphate isomerase,ZmTPI4,is required for kernel development and starch synthesis in maize(Zea mays L.)
《The Crop Journal》2024年第2期401-410,共10页Wenyu Li Han Wang Qiuyue Xu Long Zhang Yan Wang Yongbiao Yu Xiangkun Guo Zhiwei Zhang Yongbin Dong Yuling Li 
supported by the Major Public Welfare Projects of Henan Province(201300111100 to Yuling Li);Zhongyuan Scholars in Henan Province(22400510003 to Yuling Li);Tackle Program of Agricultural Seed in Henan Province(2022010201 to Yuling Li);Technical System of Maize Industry in Henan Province(HARS-2202-S to Yuling Li);State Key Laboratory of Wheat and Maize Crop Science(SKL2023ZZ05)。
Triosephosphate isomerase(TPI)is an enzyme that functions in plant energy production,accumulation,and conversion.To understand its function in maize,we characterized a maize TPI mutant,zmtpi4.In comparison to the wild...
关键词：MAIZE Kernel STARCH Weight PHOTOSYNTHESIS 
Research Article Dynamically crosslinked nanocapsules for the efficient and serumresistant cytosolic protein delivery
《Nano Research》2024年第3期1760-1771,共12页Qiang Yang Ningyu Liu Ziyin Zhao Xun Liu Lichen Yin 
supported by the Natural Science Foundation of Jiangsu Province(No.BK20220245);the National Natural Science Foundation of China(Nos.52273144 and 82241008);Collaborative Innovation Center of Suzhou Nano Science&Technology,the 111 project,Suzhou Key Laboratory of Nanotechnology and Biomedicine,and Joint International Research Laboratory of Carbon-Based Functional Materials and Devices.
Intracellular protein delivery is critical to the development of protein-based biopharmaceuticals and therapies.However,current delivery vectors often suffer from complicated syntheses,low generality among various pro...
关键词：NANOCAPSULES dynamic crosslinking cytosolic protein delivery serum resistance antitumor therapy genome editing 
Assembly of highly efficient aqueous light-harvesting system from sequence-defined peptoids for cytosolic microRNA detection被引量：1
《Nano Research》2024年第2期788-796,共9页Yang Song Xiaoli Cai Mingming Wang Dan Du Yuehe Lin Chun-Long Chen 
supported by the U.S.Department of Energy,Office of Basic Energy Sciences,Division of Materials Science and Engineering under an award FWP 65357 at Pacific Northwest National Laboratory(PNNL);the Cougar Cage Fund for the work of biological imaging and detection of microRNA.Development of peptoid synthesis capabilities was supported by the Materials Synthesis and Simulation Across Scales(MS3)Initiative through the Laboratory Directed Research and Development(LDRD)program at PNNL.XRD work was conducted at the Advanced Light Source(ALS)of Lawrence Berkeley National Laboratory;supported by the Office of Science(No.DE-AC02-05CH11231);PNNL is multi-program national laboratory operated for Department of Energy by Battelle(No.DE-AC05-76RL01830).
Precisely controlled spatial distributions of artificial light-harvesting systems in aqueous media are of significant importance for mimicking natural light-harvesting systems;however,they are often restrained by the ...
关键词：LIGHT-HARVESTING peptoid nanotube Förster resonance energy transfer intracellular RNA detection 
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