Sensing Sulfur Conditions： Simple to Complex Protein Regulatory Mechanisms in Plant Thiol Metabolism  

作　　者：Hankuil Yi Ashley Galant Geoffrey E. Ravilious Mary L. Preuss Joseph M. Jez 

机构地区：[1]Department of Biology, Washington University, One Brookings Drive, Campus Box 1137, St Louis, MO 63130, USA [2]Donald Danforth Plant Science Center, 975 North Warson Rd, St Louis, MO 63132, USA [3]Department of Biological Sciences, Webster University, 470 East Lockwood Ave, WEBH 9A, Webster Groves, MO 63119, USA

出　　处：《Molecular Plant》2010年第2期269-279,共11页分子植物（英文版）

基　　金：This work was funded by grants from the US Department of Agriculture （NRI-2005-02518） and the National Science Foundation （MCB-0824492）. No conflict of interest declared.

摘　　要：Sulfur is essential for plant growth and development, and the molecular systems for maintaining sulfur and thiol metabolism are tightly controlled. From a biochemical perspective, the regulation of plant thiol metabolism high- lights nature＇s ability to engineer pathways that respond to multiple inputs and cellular demands under a range of con- ditions. In this review, we focus on the regulatory mechanisms that form the molecular basis of biochemical sulfur sensing in plants by translating the intracellular concentration of sulfur-containing compounds into control of key metabolic steps. These mechanisms range from the simple （substrate availability, thermodynamic properties of reactions, feedback inhi- bition, and organelle localization） to the elaborate （formation of multienzyme complexes and thiol-based redox switches）. Ultimately, the dynamic interplay of these regulatory systems is critical for sensing and maintaining sulfur assimilation and thiol metabolism in plants.Sulfur is essential for plant growth and development, and the molecular systems for maintaining sulfur and thiol metabolism are tightly controlled. From a biochemical perspective, the regulation of plant thiol metabolism high- lights nature＇s ability to engineer pathways that respond to multiple inputs and cellular demands under a range of con- ditions. In this review, we focus on the regulatory mechanisms that form the molecular basis of biochemical sulfur sensing in plants by translating the intracellular concentration of sulfur-containing compounds into control of key metabolic steps. These mechanisms range from the simple （substrate availability, thermodynamic properties of reactions, feedback inhi- bition, and organelle localization） to the elaborate （formation of multienzyme complexes and thiol-based redox switches）. Ultimately, the dynamic interplay of these regulatory systems is critical for sensing and maintaining sulfur assimilation and thiol metabolism in plants.

关 键 词：ENZYMOLOGY metabolic regulation primary metabolism protein structure. 

分 类 号：Q945.3[生物学—植物学] TS201.21[轻工技术与工程—食品科学]