104名双生子青少年精神健康发育的研究  

Development of mental health of the 104 adolescents ： a twin study

作　　者：覃青[1] 傅一笑[1] 蒙华庆[1] 李涛[1,2] 陈品红[1] 欧颖[1] 罗庆华[1] 杜莲[1] 邱海棠[1] 高玉峰[1] 郑玉萍[1] 邱田[1] 

机构地区：[1]重庆医科大学附属第一医院心理卫生中心,重庆400016 [2]四川大学华西医院心理卫生中心

出　　处：《中华行为医学与脑科学杂志》2010年第5期440-443,共4页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金资助项目（30470625）

摘　　要：目的了解遗传因素对青少年双生子精神健康发育的影响。方法通过教委学校募集11岁以上的共同生活的青少年双生子。签写知情同意书后利用发育和健康状况评定（Development and WellBing Assessment，DAWBA）对双生子父母及11岁以上的双生子进行双生子精神健康发育状况的调查，并重点分析11岁以上双生子自评版的DAWBA。通过采集双生子的颊黏膜标本提取DNA进行卵型鉴定。结果DAWBA的情绪、行为症状及其症状产生的影响，计算机诊断的结果中显示情绪障碍中的分离性焦虑[同卵双生组相关系数r=0．200，P=0．28；异卵双生组（DZ）r=0．198，P=0．447]。特殊恐怖症状（rMz=0．440，P：0．013；rDz=0．419，P=0．094）、特殊恐怖症状影响（rMz=0．418，P=0．019；rnz=0．262，P=0．310）、社交恐怖症状（rMz=0．296，P=0．106；rDz=-0．119，P=0．648）、抑郁症状（rMz=0．556，P=0．001；rDz=-0．254，P=0．325）及对立违抗／品行障碍（rMz=0．503，P=0．014；rDZ=-0．270，P=0．295）及进食症状（rMz=0．764，P=0．046；rDz=-0．091，P=0．728），结果显示同卵双生组双生子相关系数大于异卵双生组。结论影响青少年精神健康发育的因素中，遗传因素起到了一定的作用。Objective To investigate the impact of genetic and environmental factors on mental health status in adolescents twins. Methods A total of 52 pairs of twins aged 11 years were recruited with support from educational committees and school. After the guardians of these twins had signed an informed consent form, the Chi- nese version growth and the state of health evaluation （ Development and Well-Bing Assessment, DAWBA） carries on twins＇ mental health growth condition investigation to the twins of Age greater than 11-year-old,and focus on analysis of DAWBA youth-assessment version of more than 11 -year-old twins. Buccal mucosa samples were collected from all twins for DNA extraction and zygosity identification test. Results The mood, the behavior symptom and the symptom produced the influence of the DAWBA and in the computer diagnosis＇ s result showed that the intra- pair correlation coefficience of the emotional disorder（ r Mz =0. 200, P=0.28; r Dz =0. 198, P=0. 447 ） （ MZ means was monozygotic, DZ means was dizygotie, r means was correlation）, the special phobia symptom （ r MZ = 0.440, P=0.013; rDZ =0.419, P=0.094） ,the social phobia （ rMz =0.296, P=0. 106; rDZ = -0. 119, P= 0. 648 ） , the depressive symptom （ r MZ = 0. 556, P = 0. 001 ; r DZ = - 0. 254, P= 0. 325 ） , and the oppositional/conduct disorder（ r MZ = 0. 503, P = 0. 014 ; r Dz = - 0. 270, P = 0. 295 ）, eating disorder（ r MZ =0. 764, P=0. 046; r Dz = -0.091, P=0.728） in Monozygotic twins was more remarkable than that in dizygotie twin. Conclusion The genetic factors play the vital role in affects in the child twins＇ mental health growth.

关 键 词：双生子 精神健康发育 遗传 发育和健康状况评定 

分 类 号：R749.94[医药卫生—神经病学与精神病学]