孕期营养与双生子散光眼形成的关系  

Relationship between nutrition in pregnancy and astigmatism formation in twins

作　　者：周文娣[1] 张佩斌 

机构地区：[1]南京医科大学第一附属医院儿童保健科江苏省妇幼卫生保健中心,江苏南京210036

出　　处：《南京医科大学学报（自然科学版）》2010年第5期705-708,共4页Journal of Nanjing Medical University(Natural Sciences)

基　　金：中疾控妇幼保健中心资助(20050125)

摘　　要：目的:探讨孕期营养与双生子散光眼形成的关系。方法:对28对双生子于生后3个月、6个月至少进行1次屈光检查,将双生子的眼散光状况与孕母孕期及双生子出生前、后的相关因素进行分析。同期随机抽取56例单胎儿作为对照。结果:双生子柱镜≥2D散光眼的检出率为53.57%,显著高于单胎婴儿(χ2=21.35,P<0.05)。双生子中有和无散光家族史的两组间,散光值比较差异有统计学意义(F=6.33,P=0.01)。母亲有早孕反应(OR=1.40,95%CI:1.10～5.13)、母亲孕中期骨密度(OR=1.44,95%CI:1.30～6.19)、血色素(OR=1.69,95%CI:1.03～2.78)、分娩时血清镁(OR=1.39,95%CI:1.03～1.89)、维生素A(OR=1.03,95%CI:1.01～1.06)、双生子脐血维生素D(OR=1.02,95%CI:1.00～1.04)和出生体重(OR=1.02,95%CI:1.00～1.03)与双生子散光眼的关联有统计学意义(P<0.05)。结论:母孕期营养状况影响双生子散光眼的形成,应在整个孕期针对性地对孕母进行营养指导,以降低婴儿散光眼的发生率。Objective：To examine the association between nutritional status of pregnant mothers and the risk of astigmatism in twins.Methods：Twenty-eight twin pairs were recruited from Jiangsu Province Hospital.Noncycloplegic refraction was measured by vision screening instrument 3 and 6 months after birth.Detailed perinatal history and postnatal data were collected.The relationship between astigmatism and related factors of pregnant mothers and infants was analyzed.Meanwhile 56 cases of singleton were randomly selected as control group.Results：Detection rate of astigmatism in observed twins＇ group was 53.57%（cylinder power of 2.0 D or worse）,which was significantly higher than that of their parents（14.28%,cylinder power of 1.0 D or worse）,and that of singletons.The values of astigmatism were correlated with family history.Morning sickness（OR=1.40,95%CI=1.10～5.13）,BMD（OR =1.44,95% CI=1.30～6.19） and haemoglobin（OR=1.40,95%CI=1.03～2.78） of mother during mid-pregnancy,maternal serum magnesium（OR= 1.39,95%CI=1.03～1.89） and vitamine A during delivery（OR=1.03,95%CI=1.01～1.05）,Umbilical vein vitamine D（OR=1.02,95% CI=1.00～1.04）,birth weight（OR=1.02,95%CI=1.00～1.03） were correlated（P 〈0.05）with the formation of twins astigmatism.Conclusion：Detection rate of twins astigmatism was significantly higher than that of singletons.The formation of astigmatism in twins was related with the level of maternal and fetal nutrition and other factors,noticeably morthers＇ morning sickness,haemoglobin and twins＇ birth weight.Further studies are warranted.Corresponding nutrition instruction should be given to pregnant women to decrease the risk of astigmatism.

关 键 词：双生子 婴儿 散光眼 孕期 营养 

分 类 号：R778.1[医药卫生—眼科]