辣椒素及其受体与肠易激综合征的相关研究  

The relationship of irritable bowel syndrome with capsaicin and vanilloid receptor 1

作　　者：刘茗[1] 靖大道[1] 

机构地区：[1]上海交通大学附属第一人民医院消化内科,上海200080

出　　处：《胃肠病学和肝病学杂志》2010年第5期472-474,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：肠易激综合征(irritable bowel syndrome,IBS)是一种常见的肠功能紊乱性疾病,特点是慢性反复发作的腹痛、腹部不适及排便习惯的改变。发病机制目前尚未阐明。研究显示IBS可能与肠道动力、内脏感觉过敏和肠道感染等因素有关,同时辣椒素及辣椒素受体对内脏痛觉的影响也受到越来越多的关注,其表达异常与IBS究竟有无关系目前尚不清楚。本文就辣椒素及其受体在理化性质、药理作用及与内脏痛觉方面的联系,以及辣椒素及其受体在IBS中的调节作用作一简要综述。Irritable bowel syndrome（IBS） is a common disease of intestinal disorders.It is characterized by chronic or recurrent abdominal pain or discomfort along with altered bowel function.The underlying mechanisms of IBS remain unclear.Several studies showed that the attack of IBS might be related to the gastrointestinal motility,visceral hypersensitivity,infection of the bowel and several other factors.This article is to review the physicochemical property,pharmacologic action and the relationship with visceral pain of capsaicin and vanilloid receptor 1 and then farther approach the accommodation in IBS,find new therapeutics.

关 键 词：肠易激综合征 辣椒素 辣椒素受体 内脏痛觉过敏 

分 类 号：R574.4[医药卫生—消化系统]