不平衡氨基酸的研究进展  

Research Progress of Amino Acid Imbalance

作　　者：金玉坤[1] 陆伟[2] 罗雁[3] 

机构地区：[1]天津市职工医院内科,天津300050 [2]天津市传染病医院肝内科,天津300192 [3]天津市海河医院内科,天津300350

出　　处：《医学综述》2010年第11期1647-1649,共3页Medical Recapitulate

摘　　要：肿瘤组织比机体能更有效地夺取氨基酸,目前临床各种氨基酸液均促进肿瘤生长,利用不平衡氨基酸,可达到抑制肿瘤生长的同时又改善机体的营养状况。大剂量精氨酸能抑制肿瘤生长;亮氨酸能增强去缬氨酸的抑瘤效应,并且能改善宿主的营养状况;蛋氨酸缺乏,将对抗肿瘤药物起着"增效剂"的作用;去缬氨酸的不平衡氨基酸抑瘤效果最为显著;谷氨酰胺浓度下降则肿瘤生长受抑制;谷氨酰胺与天冬酰胺其拮抗剂由于阻碍核酸代谢而被试用于抑制癌的增殖。针对不同类型的肿瘤制定相应的不平衡氨基酸,能更有效地抑制肿瘤生长,并改善机体营养。Tumor tissues are more likely to absorb amino acids from the body.At present,all types of amino acids used in clinical practice have obvious effects in promoting tumor growth.The amino acid imbalance will result in the overdose or deficiency of specific amino acids,both inhibiting the tumor growth and correcting the malnutrition.High-dose arginine inhibits the tumor growth; leucine boosts up the inhibitory effects of valine and improve the host＇s nutrition; the deficiency of methionine sensitizes the antineoplastics; the imbalanced valine has the most significantly antineoplastic effects; the decreased concentration of glutamine suppresses the tumor growth; glutamine and asparagine antagonist have been used in clinical trials due to their metabolic blockade of nuclear acids.Specific imbalanced amino acid regimens can effectively inhibite the proliferation of tumor and improve the nutritional status.

关 键 词：不平衡氨基酸 肿瘤 营养 抗癌治疗 

分 类 号：R735.7[医药卫生—肿瘤]