EGFR在口腔粘膜鳞癌和癌前病变中的表达及意义  

Expression and Effect of EGFR in Oral Squamous Carcinoma and Precancerous Lesions

作　　者：姚华[1,2] 吴葆萱[1,2] 吴求亮[1,2] 

机构地区：[1]浙江医科大学附属第一医院口腔科 [2]浙江医科大学附属第二医院口腔科

出　　处：《口腔医学》1999年第1期1-3,共3页Stomatology

摘　　要：应用免疫组化ＳＰ法对２３例口腔鳞癌（ＳＣＣ），２０例口腔粘膜白斑（ＬＫ），２１例口腔粘膜扁平苔藓（ＬＰ）及１０例正常口腔粘膜（ＮＭ）蜡块标本行表皮生长因子受体（ＥＧＦＲ）的定性测定．结果发现：ＳＣＣ的阳性率为８２．６１％，ＬＫ４５．０％，ＬＰ３８．１０％，ＮＭ１１．１１％．ＳＣＣ与ＬＫ、ＬＰ、ＮＭ间均有显著差别，ＬＫ、ＬＰ与ＮＭ间的差别无显著性，提示：ＥＧＦＲ高度表达可能是口腔鳞癌的重要指征之一，对癌变细胞的增殖有重要作用．The expression of epidermal growth factor receptor(EGFR) in 23 squamous,carcinomas(SCC),20 oral leukoplakia(LK),21 oral lichen planus(LP)and 10 normal mucosa(NM) was studied by immunohistochemical SP method.Result:the positive rate of EGFR in SCC,LK,LP,NM was 82.61%,45.0%,38.1%,11.11%respectively.The difference was significant between SCC and LK,LP,NM.No notable diversity was found among LK,LP,NM.It suggested that the high expression of EGFR might be one of an important biological sign of oral SCC.EGFR may play an important role in process of cell carcinogenesis.

关 键 词：鳞癌 癌前病变 口腔粘膜肿瘤 EGFR 

分 类 号：R739.85[医药卫生—肿瘤]