β淀粉样蛋白前体基因表达的研究进展  

Research advances in amyloidβprotein precursor gene expression

作　　者：陈培利[1] 童坦君[1] 

机构地区：[1]北京医科大学生化与分子生物学系,北京100083

出　　处：《生命科学》1999年第1期21-23,26,共4页Chinese Bulletin of Life Sciences

摘　　要：阿尔茨海默氏病（ＡＤ）是一主要影响老年人的退行性脑部疾患，其发生受多种因素的影响，其中β淀粉样蛋白前体的致病作用尤为引人注目。目前对该蛋白前体表达调控的研究已成为ＡＤ研究的中心之一。本文概述了该方面的新近进展，并简要评价了转基因动物模型在该研究中的应用价值。Alzheimer's disease (AD) is a primary neurodegenerative disorder mainly affectingaged people. Among the multiple factors in its etiology the role of amyloidβprotein precursor(APP) is the most conspicuous and the regulation of its gene expression had been becoming a pivotfor the last decades. In this article recent advances were summarized and the value of transgenicanimals in those researches was also reviewed.

关 键 词：阿尔茨海默氏病 基因表达 AD APP 

分 类 号：R749.16[医药卫生—神经病学与精神病学]