浸润性乳腺癌中CK5/6、EGFR以及激素受体表达的相关性分析  

Correlation analysis of the expression of CK5/6,EGFRand hormone receptors in invasive breast carcinomas

作　　者：冷冬妮[1] 王海[2] 刘英娜[1] 张曙[3] 周航波[2] 黄华[3] 陆珍凤[2] 

机构地区：[1]解放军第454医院病理科,江苏南京210002 [2]南京军区南京总医院病理科,江苏南京210002 [3]南通大学附属医院,江苏南通226001

出　　处：《现代肿瘤医学》2010年第6期1110-1113,共4页Journal of Modern Oncology

摘　　要：目的:了解浸润性乳腺癌中CK5/6、EGFR以及激素受体的表达情况及其相关性。方法:采用HE、免疫组化(EnVision法)检测146例浸润性乳腺癌。结果:146例患者均为女性,年龄33-82岁,平均54岁。组织学上部分肿瘤细胞显著多形性,核分裂象多见。免疫组化:146例浸润性乳腺癌中31例为ER、PR、HER2三阴性乳腺癌。CK5/6在浸润性乳腺癌及三阴性乳腺癌中的表达率分别为17.8%(26/146)和54.8%(17/31),EGFR在CK5/6阳性和CK5/6阴性乳腺癌中的表达率分别为65.3%(17/26)和16.6%(20/120)。Ki-67在CK5/6阳性乳腺癌中的表达率显著高于CK5/6阴性乳腺癌中的表达率。结论:基底细胞样型乳腺癌在三阴性乳腺癌中发病率较高;Ki-67在基底细胞样型乳腺癌中高表达率提示该肿瘤预后差。Objective：To observe the expression and correlation of CKS/6,EGFR and hormone receptors in invasive breast carcinomas. Methods ： One hundred and forty six cases of invasive breast carcinoma were investigated with HE staining and EnVision immunostaining. Results：All patients were females ,33 -82 years in age （mean 54 years）. Histologically,part of the tumors showed marked cellular pleomorphism and high mitotic index. Immunohistochemical- ly ,31 cases were triple negative （ ER -/PR -/HER2 - ） among the 146 cases of invasive breast carcinomas. CK5/6 was positive in 17.8% （26/146） of invasive breast carcinomas and 54.8% （ 17/31 ） of triple - negative breast carcinomas. EGFR was positive in 65.3% （17/26） of CK5/6 positive breast carcinomas and in 16.6% （20/120） of CK5/6 negative breast carcinomas. The expression of Ki - 67 was more higher in CK5/6 positive breast carcinomas than in CK5/6 negative breast carcinomas. Conclusion： Basal - like breast carcinomas have higher incidence in triple -negative breast carcinomas;high expression of Ki -67 in basal -like breast carcinomas indicates poor prognosis.

关 键 词：乳腺 基底细胞样癌 免疫组化 EGFR 

分 类 号：R737.9[医药卫生—肿瘤]