红细胞CR1和CD58数量的变化与胃良恶性溃疡的关系探讨  被引量:1

Relationship of the changes of RBC-CR1 and RBC-CD58 with benign and malignant gastric ulcer

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作  者:方辉[1,2] 施瑞华[3] 李学良[3] 

机构地区:[1]江苏省人民医院 [2]南通瑞慈医院消化科,江苏南通226010 [3]江苏省人民医院消化科

出  处:《胃肠病学和肝病学杂志》2010年第6期524-526,共3页Chinese Journal of Gastroenterology and Hepatology

摘  要:目的探讨良恶性胃溃疡患者红细胞CR1、CD58的表达及其与T细胞亚群变化的关系,为其免疫防治提供理论依据。方法采用流式细胞仪、免疫粘附法和SAP法检测良恶性胃溃疡患者红细胞CR1和CD58的数量、CR1的活性及T细胞亚群的变化。结果 35例恶性胃溃疡组红细胞CR1、CD58、C3bRR和TRR明显下降,显著低于38例良性胃溃疡组和32例正常对照组(P<0.01)。CD3+、CD4+和CD4+/CD8+在恶性胃溃疡组也显著低于良性胃溃疡组和正常对照组(P<0.01)。RBC-ICR和CD8+在恶性胃溃疡组最高,良性胃溃疡组次之,对照组最低(P<0.05)。良恶性胃溃疡组红细胞CR1的数量和活性、CD58的数量与T细胞亚群(CD4+/CD8+)呈正相关(P<0.05)。结论红细胞CR1、CD58与T细胞亚群可能参与了良、恶性胃溃疡的发生与发展。红细胞免疫可能通过CD58调控了包括T细胞亚群在内的某些免疫细胞的活性,从而共同发挥免疫防御作用。Objective To study the expression of CR1,CD58 and the correlation of them with T-lymphocyte subsets in patients with benign and malignant gastric ulcer and to provide a theoretical basis for immune therapy.Methods Flow cytometry,immune adherence rosette method and SAP assay were used to measure the quantities of RBC-CR1 and RBC-CD58,the activity of RBC-CR1 and the changes of T-lymphocyte subsets in the benign and malignant gastric ulcer group.Results The value of RBC-CR1,RBC-CD58,RBC-C3bRR and RBC-TRR were remarkably lower in the malignant gastric ulcer group than those in the benign gastric ulcer group and control group(P0.01).The percentage of CD3+,CD4+ and the CD4+/CD8+ ratio were significantly lower in the malignant gastric ulcer group compared with the benign gastric ulcer group and control subjects(P0.01).The value of RBC-ICR and CD8+ were the highest in the malignant gastric ulcer group.They were secondly in the benign gastric ulcer group and the lowest in the control group(P0.05).The CD4+/CD8+ ratio was positively correlated with the quantities of RBC-CR1,RBC-CD58 and the activity of RBC-CR1 in the benign and malignant gastric ulcer group(P0.05).Conclusion RBC-CR1,RBC-CD58 and T-lymphocyte subsets may be involved in the occurrence and development of the benign and malignant gastric ulcer.Erythrocyte immunity may regulate the activity of immunocytes including T-lymphocyte subsets by CD58.Erythrocyte immunity and T-lymphocyte subsets may have the immune prevention functions in patients with benign and malignant gastric ulcer.

关 键 词:胃溃疡 胃癌 红细胞免疫 T细胞亚群 CR1 CD58 

分 类 号:R573.1[医药卫生—消化系统]

 

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