Effects of the Aidi Dripping Pills on Immune Functions of the Tumor-bearing Mouse  

作　　者：曲韵智 关敬之 潘辉 宋延平 王友京 

机构地区：[1]School of Pharmacy,Inner Mongolia Medical College [2]Beijing Zhengda Lüzhou Medical Science and Technology Ltd.Development Co. [3]Department of Pharmacology,Shaanxi Academy of Traditional Chinese Medicine and Pharmacy

出　　处：《Journal of Traditional Chinese Medicine》2010年第2期122-125,共4页中医杂志（英文版）

摘　　要：Objective： To study the effects of Aidi Dripping Pills on immune functions of the tumor-bearing mouse on the basis of the previous experimental studies on its tumor-inhibiting and life-prolonging effects. Methods： By using the transplantation tumor mouse models, the effects of Aidi Dripping Pills on the lymphocyte transformation rate and the hemolysin formation in the Sis0 tumor-bearing mice, and on the phagocytic function of macrophages in the abdominal cavity of H22 tumor-bearing mice were investigated. Results： In the 2.25 g/kg and 1.125 g/kg Aidi Dripping Pills groups, the lymphocyte transformation rates in the Sis0 tumor-bearing mice were significantly higher than that of the control group （P〈0.01）. In all the Aidi Dripping Pills groups, HC50 significantly increased （P〈0.01 or P〈0.05）, carbon granular clearance significantly raised, and both the phagocytic index and phagocytic coefficient were significantly higher than those in the control group （P〈0.01 or P〈0.05）. Conclusion： The Aidi Dripping Pills can significantly increase the cellular immune function, the humoral immune function and the phagocytic function of the mononuclear- macrphages, so it may show anti-tumor effects by enhancing the function of the reticuloendothelial system.Objective:To study the effects of Aidi Dripping Pills on immune functions of the tumor-bearing mouse on the basis of the previous experimental studies on its tumor-inhibiting and life-prolonging effects.Methods:By using the transplantation tumor mouse models,the effects of Aidi Dripping Pills on the lymphocyte transformation rate and the hemolysin formation in the S180 tumor-bearing mice,and on the phagocytic function of macrophages in the abdominal cavity of H22 tumor-bearing mice were investigated.Results:In the 2.25 g/kg and 1.125 g/kg Aidi Dripping Pills groups,the lymphocyte transformation rates in the S180 tumor-bearing mice were significantly higher than that of the control group(P<0.01).In all the Aidi Dripping Pills groups,HC50 significantly increased(P<0.01 or P<0.05),carbon granular clearance significantly raised,and both the phagocytic index and phagocytic coefficient were significantly higher than those in the control group(P<0.01 or P<0.05).Conclusion:The Aidi Dripping Pills can significantly increase the cellular immune function,the humoral immune function and the phagocytic function of the mononuclear-macrophages,so it may show anti-tumor effects by enhancing the function of the reticuloendothelial system.

关 键 词：Aidi Dripping Pills immune function MOUSE 

分 类 号：R73-3[医药卫生—肿瘤]