NDPK/nm23-H_1在膀胱癌、肺癌、大肠癌中的表达及意义  

Expression and significance of NDPK/nm23-H 1 in human cancer tissues of bladder、lung and large intestine

作　　者：赵春华[1] 唐卫华[1] 汪筱娟[1] 康鲁东[1] 罗道春[1] 张虞毅[1] 胡晓燕[1] 

机构地区：[1]山东医科大学生物化学教研室

出　　处：《肿瘤防治研究》1999年第1期24-25,共2页Cancer Research on Prevention and Treatment

基　　金：山东省自然科学基金

摘　　要：收集石腊包埋组织标本膀胱癌８０例、肺癌６９例、大肠癌３７例，对有转移者同时收集其转移灶标本，应用免疫组织化学法检测ＮＤＰＫ／ｎｍ２３－Ｈ１的表达情况。结果显示：ＮＤＰＫ／ｎｍ２３－Ｈ１在膀胱癌、肺癌和大肠癌中表达的阳性率分别为６４％、８０％和９４％；其表达水平在膀胱癌、大肠癌与分化程度有关，随分化程度降低而显著降低（Ｐ＜００５）；在肺癌与组织学类型有关，以肺鳞癌中最高，其次为腺癌和小细胞癌（Ｐ＜００５）；在大肠癌与淋巴结转移有关，伴淋巴结转移者其原发灶中显著降低（Ｐ＜００１）；对原发灶和转移灶的配对分析，未发现相关性。提示ＮＤＰＫ／ｎｍ２３－Ｈ１表达水平是一个与肿瘤恶性行为相关的因素，但其临床意义存在组织学差异。To elucidate its clinical significance in human cancer tissues,the expression of NDPK/nm23-H 1 was detected by immunohistochemical technique.Results:In cancer tissues of bladder、lung and large intestine,the positive staining rates were 64%(51/80)、80%(55/69) and 94%(35/37) respectively;Both in bladder and in large intestine tissues,the immunoreactivity of NDPK/nm23-H 1 was possitively correlated with the cancer cell differentiation ( P <0 05);Moreover in lung cancer tissues,there was relationship between the immunoreactivity and the cell types,it was higher in squamous cell carcinoma than that in adenocarcinoma and small cell carcinoma;In addition in Large intestine cancer tissues,the immunoreactivity was negatively related with the metastasis pertential of lymph nodes ( P <0 05).These results suggest that the immunoreactivity of NDPK/nm23-H 1 was indeed related to the malignancy of tumor,but its clinical significance was varied in different tissues.

关 键 词：NDPK NM23-H1 免疫组织化学 肿瘤转移 膀胱肿瘤 

分 类 号：R73－37[医药卫生—肿瘤] R737.14[医药卫生—临床医学]