植物雌激素对老年性大鼠股骨生物力学特性的影响  

Effect of Soybean Meal Derived Phytoestrogen on Biomechanical Characteristics of Femur in Senile Rats

作　　者：赵丽英[1] 张二芹[1] 刘声[2] 杜瑞卿[1] 高允海[3] 黄豪[4] 

机构地区：[1]南阳师范学院生命科学与技术学院,河南南阳473061 [2]北京中医药大学基础医学院,北京100029 [3]辽宁中医药大学第一附属医院普外科,辽宁沈阳110032 [4]南阳师范学院体育学院,河南南阳473061

出　　处：《食品科学》2010年第11期234-237,共4页Food Science

基　　金：河南省教育厅基础研究资助项目(2007890009);南阳师范学院生物化学与分子生物学重点学科资助项目

摘　　要：目的:揭示植物雌激素对老年性骨生物力学的影响程度。方法:选取120只老龄性SD清洁级大鼠,分成4组,每组分别喂养3个月、6个月和10个月的不同批次处死,取股骨测量6项生物力学指标,并进行统计分析。结果:植物雌激素在10个月、6个月和3个月不同时期都表现出能增强骨生物力学特性的作用,能改善骨质量;而单纯依靠增加钙剂量在6个月和3个月内作用却不明显,10个月内可以改善骨生物力学的特性,但不全面;在使用植物雌激素的同时,增加钙含量,对改善骨生物力学的特性更好。结论:单纯食钙对预防骨质疏松症和改善骨质量的作用有限,经常适量食用含植物雌激素丰富的大豆或大豆制品对预防骨质疏松症和较全面改善骨质量有积极意义。Objective：To evaluate the effect of phytoestrogen contained in soybean meal on biomechanical characteristics of bone in senile rats.Methods：Totally 120 senile male SD rats were randomly divided into 4 groups,which were fed common diet（as the control）,common diet plus calcium,common diet plus phytoestrogens,and common diet plus calcium and phytoestrogen,respectively.The rats in every group were partially sacrificed after 3,6 or 10 months of feeding.The biomechanical characteristics of the femur in senile rats were analyzed.Results：The administration of phtoestrogen,could enhance biomechanical characteristics and improve bone quality in rats regardless of length of administration time（3,6 or10 months）,which was superior to the administration of calcium alone.The administration of calcium alone for 3 or even 6 months had no obvious beneficial effects on biomechanical characteristics and bone quality in rats;an improvement in some but not all of biomechanical characteristics in rats,howevers observed when the length of administration time was prolonged to 10 months.In the presence of phytoestrogen,increasing calcium amount resulted in a better improvement in biomechanical characteristics.Conclusion：The intake of calcium alone has a limited effect in preventing osteoporosis and in improving bone quality.Comparatively,the frequent consumption of soybean or soybean products has positive significance for preventing osteoporosis and improve bone quality.

关 键 词：植物雌激素 骨生物力学特性 实验研究 

分 类 号：R151.3[医药卫生—营养与食品卫生学]