蛹虫草对D-半乳糖模型鼠记忆能力的影响  

Effect of Cordyceps militaris on Learning and Memory Capability of D-Galactose-induced Aging Mouse Model

作　　者：杨占军[1] 张健[1] 汤阳[1] 温鲁[1] 

机构地区：[1]淮阴师范学院生命科学学院,江苏淮安223300

出　　处：《食品科学》2010年第11期252-254,共3页Food Science

基　　金：江苏省高校自然科学基金项目(05KJB180010);淮阴师范学院教授基金项目(06HSJS027)

摘　　要：目的:探讨蛹虫草对D-半乳糖模型小鼠学习记忆能力的影响。方法:使用D-半乳糖建立小鼠衰老模型,用蛹虫草灌胃进行实验性治疗。持续6周后,通过避暗实验、穿梭箱实验和跳台实验检测小鼠的学习记忆能力。结果:与对照组相比,模型组小鼠的学习、记忆能力下降(P<0.05或P<0.01);与模型组相比,蛹虫草组的学习、记忆能力有不同程度地得到恢复(P<0.05)。结论:蛹虫草可改善由D-半乳糖所导致的学习、记忆障碍。Objective：To explore the effect of Cordyceps militaris on learning and memory capability of D-galactose-induced aging mouse model.Methods：An aging mouse model was established through the induction of D-galactose,and the experimental mice（assigned to the model group） were by gavage administered with Cordyceps militaris for 6 consecutive weeks and the Cordyceps militaris treated group was obtained.After the end of the administration,the mice were evaluated for their learning and memory capability by dark avoidance test,shuttle-box test and step-down test.Results：Compared with the control group,the learning and memory capability of mice in model group exhibited a significant decrease（P〈0.05 or P〈0.01）;While,compared with the model group,the learning and memory capability of mice the Cordyceps militaris treated group exhibited an obvious recovery（P〈0.05）.Conclusion：Cordyceps militaris can significantly improve learning and memory capability of aged mice.

关 键 词：蛹虫草 衰老 记忆障碍 改善作用 

分 类 号：O622.4[理学—有机化学]