纳豆激酶对视网膜中央静脉阻塞动物模型中闪光视网膜电图的影响  

The effect of nattokinase on electrophysiological changes of retina in rabbit eyes with central retinal vein occlusion

作　　者：占慧琴[1] 袁志兰[1] 杨翎[1] 孙红[1] 

机构地区：[1]南京医科大学第一附属医院眼科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2010年第7期974-976,1016,共4页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的:评价纳豆激酶对兔视网膜中央静脉阻塞(central retinal vein occlusion,CRVO)视网膜功能是否有改善作用。方法:采用氩激光直接光凝法建立兔CRVO模型成功后,纳豆激酶组(A组)连续3天玻璃体腔注射0.1FU纳豆激酶提取液0.1ml;林格氏液组(B组)同方法注射林格氏液0.1ml;空白模型组(C组)未外加处理。检测3组光凝前、光凝后2周闪光视网膜电图(FERG)。结果:①激光可以建立兔CRVO模型,造模成功后FERG-a、FERG-b波潜伏期较造模前明显延长;②A组FERG-a、FERG-b波潜伏期较B、C组明显缩短(P<0.05)。结论:激光致兔CRVO模型是成功的,纳豆激酶可部分改善视网膜功能。Objective：To study the effect of nattokinase on visual functions in rabbit eyes with central retinal vein occlusion（CRVO）.Methods：Central retinal vein occlusion of rabbit model was established with argon laser photocoagulation to retinal vein.After laser,intravitreal injections of either 0.1 ml of 0.1 FU nattokinase,or Ringer＇s solution（negative contro1）were given once daily for three days.And the group C as control was not given any treatment.Before and 14 days after laser,flash electroretinogram（FERG）was recorded and statistically analyzed.Results：Argon laser photocoagulation induced an experimental model of central retinal vein occlusion.Statistically significant difference existed in latencies of FERG-a and FERG-b among the groups（P0.05）.Conclusion：An experimental model of central retinal vein occlusion was successfully produced in rabbit by argon laser photocoagulation.Nattokinase can ameliorate visual functions.

关 键 词：纳豆激酶 视网膜中央静脉阻塞 闪光视网膜电图 兔 

分 类 号：R774[医药卫生—眼科]