山东省双相情感障碍6号染色体基因扫描研究  

A search for susceptibility genetic loci to bipolar disorder on chromosome 6

作　　者：栾萌[1] 陈刚[1] 周鹏[1] 常学润[2] 王元勋[2] 杨树林[1] 陈星[1] 刘文敏[1] 范文田[2] 

机构地区：[1]山东省医学科学院基础医学研究所,济南250062 [2]山东省精神卫生中心

出　　处：《精神医学杂志》2010年第3期161-164,共4页Journal of Psychiatry

基　　金：山东省自然科学基金重点项目Z2008C11;山东省大型仪器更新改造项目2008GG27C01011-8;山东省医学科学院项目2009-15

摘　　要：目的对双相情感障碍患者及正常对照者的6号染色体进行扫描,查找双相情感障碍的关联位点,进而定位易感基因。方法在6号染色体上间隔10cM(厘摩)遗传距离选择了20个微卫星遗传标记,对104例发病年龄≤20岁的双相情感障碍患者与1000例正常对照者组成的DNA混合样本分别进行了扫描。采用CLUMP软件进行统计学分析,逐一比较患者组与对照组等位基因频率的差异。结果在D6S262位点发现患者组与对照组的等位基因频率差异有显著性意义(P<0.05)。结论山东省双相情感障碍患者与6号染色体上D6S262位点关联,基因突变或甲基化调控等致病因子可能位于其附近。Objective A screen on chromosome 6 was carried out for finding the associated genetic loci for bipolar disorder. Methods A total of 20 microsatellite markers on chromosome 6 spaced at about 10 cM were selected and two DNA pooling samples consisting of 104 bipolar disorder cases and 1000 normal controls were genotyped respectively. Statistic analysis was performed by Chi -square method with CLUMP software to compare the difference in frequency of each allele of these loci between the two pooling samples. Results Significant difference was found at D6S262 locus be- tween cases and controls, P 〈 0.05 . Conclusion D6S262 on chromosome 6 is associated with bipolar disorder in the population of Shandong province, and further screening of the susceptibility gene around this locus is needed.

关 键 词：双相情感障碍 染色体 遗传 基因 DNA 混合池 

分 类 号：R749.4[医药卫生—神经病学与精神病学]