酪氨酸-乳酸-乙醇酸共聚物的合成与表征  

Synthesis and characterization of biodegradable poly(L-tyrosine-co-lactic acid-co-glycolic acid)(PTLG) copolymers

作　　者：雷自强[1] 刘杰[1] 王海江[1] 路德待[1] 

机构地区：[1]西北师范大学化学化工学院,生态环境相关高分子材料教育部重点实验室,甘肃兰州730070

出　　处：《西北师范大学学报（自然科学版）》2010年第4期70-73,共4页Journal of Northwest Normal University(Natural Science)

基　　金：甘肃省高分子材料重点实验室资助项目(ZD-05-02);西北师范大学三期科技创新工程青年项目

摘　　要：以乳酸、乙醇酸和L-酪氨酸在SnCl2.2H2O催化下一步合成了两亲性聚(酪氨酸-乳酸-乙醇酸)共聚物(PTLG).核磁共振谱分析证实聚乳酸(PLA)、聚乙醇酸(PGA)以及聚酪氨酸(PT)结构单元进入了PTLG分子链中.分别采用凝胶渗透色谱(GPC)和核磁(1HNMR)及热重(TGA)分析对共聚物的平均分子量及热稳定性进行了测定.结果表明,共聚物的数均分子量均在3000以上,且分解温度高于150℃;由于PTLG分子链中存在聚酯和聚酰胺链段及酚羟基侧基,使其在部分极性有机溶剂中有一定的溶解性,且具有pH敏感性.Poly（L-tyrosine-co-lactic acid-co-glycolic acid）（PTLG）,an amphiphilic polymer,is synthesized by simply heating a mixture of L-tyrosine（Tyr）,DL-lactic acid and glycolic acid in the present of stannous chloride.1HNMR analysis confirms that PTLG chains contain PLA,PGA and poly（L-tyrosine）units.Molecular weights and thermal properties are determined by GPC,1HNMR and TGA.The results show that number-average molecular weights of the copolymers are more than 3000,and the decomposition temperature are more than 150 ℃.Because of containing polyester,polyesteramides and phenolic hydroxyl groups,PTLG has good solubility in some polar organic solvents and has good pH sensitivity.

关 键 词：熔融缩聚 聚酯酰胺 乳酸 氨基酸 

分 类 号：O631.61[理学—高分子化学]