头花蓼对α-葡萄糖苷酶的抑制活性研究  

Inhibitory Activity of Polygonum Capitatum to α-Glucosidase

作　　者：陈百泉[1] 李昌勤[1] 常星[1] 康文艺[1] 

机构地区：[1]河南大学中药研究所,河南开封475004

出　　处：《中国实验方剂学杂志》2010年第8期151-153,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河南省教育厅基础研究计划(2009B360001);河南省教育厅青年骨干教师资助计划(教高[2008]755)

摘　　要：目的:研究头花蓼不同溶剂提取物对α-葡萄糖苷酶的抑制活性。方法:采用索氏提取法对头花蓼进行不同溶剂提取,以体外法测定各提取物对α-葡萄糖苷酶的抑制作用。结果:头花蓼各提取物均具有较好的α-葡萄糖苷酶抑制活性。其中头花蓼的甲醇提取物抑制活性最高(IC50 1.68μg·mL-1),乙酸乙酯提取物(IC50 7.27μg·mL-1)和石油醚提取物(IC50 116.81μg·mL-1)的活性次之。3个提取物活性均远大于阳性对照acarbose(IC50 1081.27μg·mL-1)。且各提取物对α-葡萄糖苷酶的抑制作用均具有剂量依赖性。结论:头花蓼甲醇提取物对α-葡萄糖苷酶活性的抑制效果非常显著,具有很好的开发价值。Objective：To investigate different extracts of Polygonum capitatum on inhibitory activity to α-glucosidase.Method：Different extracts were extracted by Soxhlet,and the inhibitory activity to α-glucosidase was screened by the 96-microplate-based method.Results：The results showed that P.capitatum had good inhibitory activity.The methanol extract had the highest inhibitory activity to α-glucosidase （IC50 1.68 μg·mL-1）,and then the ethyl acetate extract （IC50 7.27 μg·mL-1） and the petroleum ether extract （IC50 116.81 μg·mL-1 ）,three extracts of P.capitatum showed higher activity than Acarbose （IC501 081.27 μg·mL-1）.And all of the extracts showed dose dependent for the inhibitory activity.Conclusion：The methanol extract of P.capitatum showed very significant inhibitory activity to α-glucosidase,and could be exploited the diabetes drugs as α-glucosidases inhibitors in future.

关 键 词：头花蓼 Α-葡萄糖苷酶 抑制活性 

分 类 号：R285.5[医药卫生—中药学]