儿童急性白血病发病机制的研究进展  

Progress in pathogenesis of childhood acute leukemia

作　　者：邹黎(综述)[1] 周国平(审校)[1] 

机构地区：[1]南京医科大学第一附属医院儿科,210029

出　　处：《国际儿科学杂志》2010年第4期368-371,共4页International Journal of Pediatrics

基　　金：基金项目：国家自然科学基金资助项目（30872804,30570863）;江苏省自然科学基金资助项目（BK2007244）;江苏省医学重点人才资助项目（RC2007050）

摘　　要：急性白血病是儿童最常见的恶性肿瘤之一,其病因及发病机制仍未完全明确.目前已证明大部分急性白血病有克隆性染色体异常,TEL/AML1、BCR/ABL、PML/RAR-α等是常见的融合基因,通过对其检测可指导疾病诊疗和预后判断.近期的研究发现基因多态性也与白血病的易患性相关,如叶酸代谢相关基因、细胞色素P450和谷胱甘肽s-转移酶、苯醌氧化还原酶-1等.此外,酒精、烟草、肿瘤坏死因子α、干扰素均是致白血病发生的潜在危险因素,而干扰素调节因子-3和婴幼儿早期感染则也许能减少白血病的发生.Acute leukemia is one of the most common cancers among children.The biological mechanisms leading to leukemia have not been fully clarified until now.Experiments were improved that most patients developing acute leukemia had abnormal chromosomes,including TEL/AML-l,BCR/ABL,PML/RAR-α fusion genes,which would be potential clinical biomarkers.Many genetic polymorphisms have effect on acute lymphoblastic leukemia susceptibility,which were containing genes involved in folate metabolism pathways,cytochrome P450,glutathione-S-transferase enzymes and quinone oxidoreductase-1.As the results of the studies,alcohol,tobacco,TNF-α and IFN-γ might be risk factors to the disease.Furthermore infection and IRF-3 were reported to reduce the occurrence of acute leukemia.Finally,as more is learned about the molecular pathology,it may be possible to develop new therapeutic agents which are specifically targeted to treat childhood acute leukemia.

关 键 词：白血病 融合基因 基因多态性 细胞因子 

分 类 号：R733.71[医药卫生—肿瘤]