p16蛋白和表皮生长因子受体在肝癌中的表达及其意义  

Expressions and thdir significances of p16 protein and epidermal growth factor receptor (EGFR) in hepatocellular carcinoma

作　　者：孙丽萍[1] 曹敏[1] 陈培辉[1] 

机构地区：[1]浙江医科大学附属第二医院病理科,杭州310009

出　　处：《癌症》1999年第1期37-38,85,共3页Chinese Journal of Cancer

摘　　要：目的：研究肝细胞癌p16蛋白及EGFR的表达及其临床病理学的意义。方法：应用p16蛋白及EGFR抗体，用S－P免疫组织化学技术进行观察。结果：50例肝细胞癌中32例（64％）p16蛋白阳性，36例（72％）EGFR阳性。P16蛋白阳性率在高分化型（包括梁状型及假腺管型）为88％（22／25），而低分化型（包括实团型与纤维硬化型）为40％（10／25），两者有明显的统计学差异（P＜0．01）。高分化型EGFR阳性率为52％（13／25），而低分化型为92％（23／25），两者也有明显差异（P＜0．01）。结论：P16及EGFR表达与肝细胞癌组织学分型及分级有关。Objective:To study expressions of p16 protein and EGFR and their clinicopathalogical significances in hepatocellular carcinoma. Methods: Using S-P immunohistochemical technique with p16 protein and EGFR antibodies, 50 cases with the tumor were investigated. Results:32 cases (64%) were posititve for p16 protein and 36 cases (72% ) for EGFR in 50 cases with hepatocellular carcinoma.The rate of p16 in well differentiated type (including the trabecular and the pseudo-glandular) was 88% (22/25), and the poorly differentiated one (including the compact and the scirrhous) 40% (10/25), with statisticlly significant difference between them (P<0.01).The rate of EGFR in the well-differentiated was 52% (13/25) and the poorly differentiated 92% (23/25), also with statistically significant difference (P<0.01) Conclusions:The expressions of p16 and ECFR may be related to histological typing and grading of the tumor.

关 键 词：肝肿瘤 P16基因 MTS1 EGFR 

分 类 号：R735.702[医药卫生—肿瘤]