原发性膀胱癌肿瘤浸润淋巴细胞体外抗肿瘤作用的研究  

In vitro antitumor activity of tumor infiltrating lymphocytes from a patient with bladder cancer

作　　者：裴秀英[1,2] 韩梅[1,2] 杨志伟 梁大用[1,2] 王慕娣 戴寿芝[1,2] 

机构地区：[1]宁夏医学院免疫研究室 [2]宁夏医学院附属医院泌尿外科

出　　处：《宁夏医学杂志》1999年第2期65-66,共2页Ningxia Medical Journal

摘　　要：目的探讨原发性膀胱癌肿瘤浸润淋巴细胞（ＴＩＬ）的体外抗肿瘤作用。方法采用ＬＤＨ释放法。结果该ＴＩＬ对自体肿瘤靶细胞的最高杀伤活性第３０天时为７２．４％，且呈现一定的靶细胞特异性。结论膀胱癌ＴＩＬ在体外经ＩＬ－２培养后对自体肿瘤细胞具有明显的杀伤活性。Objectives To study the antitumor activity in vitro of Tumor infiltrating lymphocytes (TIL) from a patient with bladder cancer.Methods Using the LDH release assay.Results The TILs showed the highest antitumor activity (72.4%) and target specificity.Conclutions After incubation of TILs in medium with IL-2,the TILs exhibited apparently antitumor activity and specificity to autotumor cells

关 键 词：肿瘤浸润 白细胞介素-2 膀胱肿瘤 TIL 

分 类 号：R737.140.2[医药卫生—肿瘤]