广东人群非综合征型唇腭裂发病危险因素研究  

STUDY ON RISK FACTORS OF NONSYNDROMIC CLEFT LIP AND PALATE IN CHINESE GUANGDONG POPULATION

作　　者：舒申友 唐世杰[1] 吴燊荣[1] 陈伟练[1] 

机构地区：[1]汕头大学医学院第二附属医院唇腭裂治疗中心,广东汕头515041

出　　处：《中国修复重建外科杂志》2010年第8期962-966,共5页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：广东省自然科学基金资助项目(9151503104000001)~~

摘　　要：目的探讨广东人群非综合征型唇腭裂(nonsyndromic cleft lip and palate,NSCLP)发病的危险因素及主要危险因素间的交互作用。方法采用回顾性病例对照研究,选择2009年9月-2010年3月汕头大学医学院第二附属医院唇腭裂治疗中心收治的广东籍NSCLP患儿作为病例组,同期入住该院其他科室的广东籍非NSCLP患儿作为对照组。针对NSCLP发病的可能影响因素制定统一问卷,对两组患儿父母进行调查。所得数据作卡方检验和多因素非条件logistic回归分析。结果研究实际纳入病例组105例,对照组110例,平均年龄分别为2.2岁和3.0岁。logistic回归分析筛选出有意义的影响因素为:唇腭裂遗传家族史(OR=4.210,P=0.039)、母亲异常生育史(OR=2.494,P=0.033)、妊娠早期用药史(OR=3.488,P=0.000)及妊娠早期情绪异常史(OR=3.416,P=0.011)。遗传家族史与母亲异常生育史、妊娠早期用药史在NSCLP的发生上存在正交互作用。结论唇腭裂遗传家族史、母亲异常生育史、妊娠早期用药史及妊娠早期情绪异常史为广东人群NSCLP发病危险因素,提示可通过干预相关环境因素降低其发病率。Objective To investigate the association between environmental factors and nonsyndromic cleft lip and palate （NSCLP）, and to explore the interaction of main risk factors in Chinese Guangdong population. Methods A hospital-based case-control study was used. NSCLP children were selected from Cleft Lip Palate Treatment Centre of Second Affiliated Hospital of Medical College of Shantou University between September 2009 and March 2010 as cases. And controls were chosen from other departments in the same hospital during the same period. The parents of cases and controls were inquired regarding the risk factors and the answers were filled in a unification questionnaire by physicians. These data were analysed with chi-square test and multivariate unconditional logistic regression analysis. Results A total of 105 cases and 110 controls with a mean age of 2.2 years and 3.0 years, respectively, were enrolled. Multivariate logistic regression analysis revealed that genetic family history （OR=4.210, P=0.039）, mothers’ abnormal reproductive history （OR=2.494, P=0.033）, early pregnancy medication （OR=3.488, P=0.000）, and maternal stress （OR=3.416, P=0.011） were risk factors. There were positve interactions between genetic family history and mothers’ abnormal reproductive history as well as early pregnancy medication. Conclusion Certain influencing factors including genetic family history, mothers’ abnormal reproductive history, early pregnancy medication, and maternal stress are associated with NSCLP among Chinese Guangdong population. This study suggests that it may reduce the incidence rate of NSCLP through environmental intervention.

关 键 词：非综合征型唇腭裂 危险因素分析 LOGISTIC回归 病例对照研究 

分 类 号：R782.21[医药卫生—口腔医学]