豫西地区女性宫颈病变HPV感染分子流行病学探讨  

Molecular Epidemiological Study of Human Papillomavirus Infection Among Cervicitis Patients in Yuxi Region

作　　者：吴向晖[1] 杜趁香[1] 王焱[1] 孙宗立[1] 阎慧娟[1] 

机构地区：[1]河南科技大学第一附属医院,河南洛阳471000

出　　处：《实用预防医学》2010年第8期1505-1506,共2页Practical Preventive Medicine

摘　　要：目的探讨人乳头瘤病毒（Human papillomavirus,HPV）21种基因型在豫西地区女性宫颈病变中的分子流行病学特点。方法对豫西地区因宫颈病变或可疑HPV感染就诊的1540位女性进行HPV基因分型检测,共21种基因型,比较不同基因型的流行病学特点。结果本组资料中总的HPV感染比例为31.8%（489/1540）,共检出21种基因亚型,高危型占35.13%,低危型占5.39%,单一感染占23.25%,双重感染或多重感染占8.51%,高危型最常见类型为HPV16、58、31,低危型最常见类型为HPV6、11。不同年龄段HPV感染率,最高为31-40岁组,占45.4%,其次为21-30岁组,占30.6%。结论本研究提供了21种HPV基因型在豫西地区的分子流行病学资料,对该地区疫苗开发、应用具有重要价值,为临床防治宫颈癌提供可靠的科学依据。Objective To explore the molecular epidemiological characteristics of 21 genotypes of human papillomavirus（HPV）in Yuxi region.Methods The HPV types were determined among 1,540 women who were suspected to be suffering from HPV infection or cervix lesion in Yuxi Region.The molecular epidemiological characteristics of 21 HPV types were compared.Results The total positive rate of HPV was 31.8%（489/1,540）.21 isoforms were checked out in these women,high-risk form accounted for 35.13%,low-risk form 5.39%,single isoform 23.25%,and double-or multi-isoforms 8.51%.HPV16,58,and 31 were mostly seen in high-risk form and HPV6 and 11 were mostly seen in low-risk form.The positive rate of HPV of the age group of 30～40 years was the highest（45.5%）,followed by the age group of 21～30 years（30.6%）.Conclusions This article offers molecular epidemiological characteristics of 21 genotypes of HPV and provides the reliable and scientific evidence for prevention and treatment of cervical cancer in Yuxi Region.And it is of great value to develop and apply HPV vaccine in this region.

关 键 词：HPV 基因型 高危型 宫颈病变 

分 类 号：R737.33[医药卫生—肿瘤]