大前庭水管综合征与内耳其他畸形的听性脑干反应特性分析  

The clinical significance of ABR testing in the diagnosis of the large vestibular aqueduct syndrome

作　　者：郝剑萍[1] 赵岩[1] 闫文斐[1] 师天祥[1] 

机构地区：[1]甘肃省康复中心医院耳鼻咽喉科,兰州730000

出　　处：《临床耳鼻咽喉头颈外科杂志》2010年第13期598-600,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：甘肃省自然科学基金项目(No:096RTZA020)

摘　　要：目的：通过对大前庭水管综合征（LVAS）与内耳其他畸形的听性脑干反应（ABR）特性进行分析,了解在进行ABR检查过程中出现声诱发短潜伏期负相波（ASNR）对诊断LVAS的特异性。方法：对2008-01-2009-09患感音神经性聋（SNHL）的患儿进行颞骨薄层CT扫描,将其中70例内耳其他畸形患儿的影像学结果进行分析,并将研究对象分组,LVAS组（包括大前庭伴其他内耳畸形）38例（76耳）,内耳其他畸形组32例（64耳）,在进行行为测听或纯音测听、声导抗、耳声发射听力学检查项目的基础上,均进行ABR检测。结果：ABR检查发现24例（41耳）大前庭水管,在2~3 ms处记录到特征性的负相波,检出率为54%,在这41耳中,轻度听力下降2耳、中度听力下降1耳,重度听力下降5耳,极重度听力下降33耳。内耳其他畸形组未检测到负相波。2组差异有统计学意义（P〈0.05）。结论：在LVAS与内耳畸形的ABR特性分析中,LVAS无论是否伴其他内耳畸形,无论听力损失的程度如何,均有可能检测出负相波,认为ASNR是大前庭水管综合征临床听力学特征性表现之一。Objective：To analyse the clinical audiological significance in the diagnosis of large vestibular aqueduct syndrome（LVAS）by the auditory brain stem response（ABR） testing.Method： Patients with sensorinenural hearing loss were examined by temporal bone CT scaning from January,2008 to September,2009.The result of CT scanning of 70 cases inner ear malformation were analysed.Patients were devided into two groups,LVAS group including 38 cases（76 ears）and other inner ear malformation group including 32 cases（62 ears）.All patient accepted clinical audiology analysis and auditory brainstem respone（ABR） test.Result： Twenty-four cases（41 ears） of LVAS group were detected with ASNR in 2~3 cm by the ABR testing,the positive rate was 54%,while ASNR was not detected in patients of other inner ear malformations group.There was significant differences（P=0.01）of the ASNR between two groups.Conclusion：There is high incidence of LVAS on the patients with Non-syndromic deafness.ASNR by ABR testing could help diagnosing the LVAS.

关 键 词：声诱发短潜伏期负相波 内耳畸形 大前庭水管综合征 听性脑干反应 

分 类 号：R764[医药卫生—耳鼻咽喉科]