氨甲苯酸与酚磺乙胺配伍用药的细菌内毒素定量研究  

Quantitative Detection of Bacterial Endotoxin Test for Combination of Aminomethylbenzoic Acid and Etamsylate Injection

作　　者：李楚云[1] 詹云丽[2] 刘杜妙[2] 翁嘉[2] 陈健红[1] 

机构地区：[1]惠州市中心人民医院,广东惠州516001 [2]广东省惠州市药品检验所,广东惠州516003

出　　处：《今日药学》2010年第8期11-13,共3页Pharmacy Today

基　　金：2009年度惠州市第一批(医疗卫生)科技计划项目(编号:2009Y014)

摘　　要：目的以动态浊度法研究氨甲苯酸、酚磺乙胺注射液联合用药输液器终端混合液的细菌内毒素检查干扰情况,建立其细菌内毒素的定量分析方法,为临床合理用药提供检验依据。方法采用《中国药典》2005年版二部动态浊度法定量检测细菌内毒素含量。结果输液配伍后混合液稀释10倍能排除干扰。结论动态浊度法测定此混合液细菌内毒素含量是可行的。Objective To investigate the bacterial endotoxin test interference for aminomethylbenzoic acid and etamsylate injection drug infusion terminal by turbidimetric kinetic method,to establish quantitative analysis method of bacterial endotoxin and provide testing basis for the clinical rational drug application.Methods The turbidimetric kinetic assay was adopted to quantitatively analyze the content of bacterial endotoxin,according to China Pharmacopoeia（2005 Edition 2）.Results The combined infusion which was diluted 10-folds had no interference on the test.Conclusion The turbidimetric kinetic assay can be used to determine the content of bacterial endotoxin of this mixture.

关 键 词：细菌内毒素 联合用药 动态浊度法 

分 类 号：R96[医药卫生—药理学]