反义脱氧寡核苷酸对SRS病毒复制的抑制作用  

INHIBITION OF SRS VIRUS REPLICATION BY ANTISENSE OLIGODEOXYNUCLEOTI DES

作　　者：单易非[1] 纪宏[1] 裘慕绥[2] 王德宝[2] 

机构地区：[1]上海医科大学基础医学部生物物理学教研室 [2]中国科学院上海生物化学研究所

出　　处：《上海医科大学学报》1990年第6期435-438,共4页Journal of Fudan University(Medical Science)

摘　　要：用合成的反义脱氧寡核苷酸,包括修饰的和非修饰的,同聚的和异聚的脱氧寡核苷酸对SRS病毒感染细胞的增殖、细胞群落形成,XC融合细胞产生的抑制作用。结果表明,上述的寡聚物对病毒都有抑制活性。各种寡聚物的作用机制不同。Synthesized antisense oligodeoxynuoleotides, including their modified and unmodified,homo-and hetero forms were tested for their ability to inhibit mouse SRS virus-induced cellular multiplication, formations of colonies of SRSV-infected cells and XC synoytia. All oligomers were found to be active. Results Suggest that different classes of oligonuoleotidee inhibit virus replication by different mechanisms.

关 键 词：反义寡核苷酸 抗病毒 SRS病毒 

分 类 号：R733.703[医药卫生—肿瘤]