螺旋藻对四氯化碳急性中毒小鼠肝组织保护作用的研究  

A Study on the Protective Effect of Spirulina Platensis on the CCl4induced Liver Tissue Injury of Mice

作　　者：张小强[1] 陆琮明[1] 翟成凯[1] 

机构地区：[1]南京铁道医学院营养与食品卫生学教研室

出　　处：《南京铁道医学院学报》1999年第2期101-102,共2页Journal of Nanjing Railway Medical College

摘　　要：目的：探讨螺旋藻对四氯化碳（ＣＣｌ４）染毒小鼠急性化学性肝损伤的保护作用。方法：采用ＣＣｌ４建立小鼠急性化学性肝损伤模型，研究螺旋藻对损伤是否具有保护作用。结果：连续２５ｄ经口给实验组小鼠螺旋藻０．８３、１．６７、２．５０ｇ·ｋｇ１，可降低ＣＣｌ４染毒小鼠的血清ＡＬＴ和ＡＳＴ水平，减轻ＣＣｌ４对肝组织的病理损伤。结论：螺旋藻对ＣＣｌ４所致小鼠急性化学性肝损伤具有保护作用。Objective: The aim of the experiment was to study the protective effect of spirulina platensis on the CCl4induced liver tissue injury of mice. Method: The protective effect of spirulina platensis on the liver tissue damage were studied by model of CCl4intoxication mice. Result: A decreased ALT and AST activity of serum in CCl4intoxicated mice after 0.83gkg1,1.67gkg1 and 2.50gkg1 of spirulina platensis had been given orally for 25 days and the damage on liver cell was alleviated. Conclusion: It is suggested that spirulina platensis posseses a protective effect on liver tissue of CCl4intoxicated mice.

关 键 词：螺旋藻 四氯化碳中毒 肝组织损伤 肝保护 小鼠 

分 类 号：R931.77[医药卫生—生药学] R595.4[医药卫生—药学]