胃癌与内源性亚硝酰胺的合成  

GASTRIC CANCER AND ENDOGENOUS N-NITROSAMIDE SYNTHFSIS

作　　者：贺立新[1] 王丽岩[1] 

机构地区：[1]内蒙古医学院第一附属医院

出　　处：《内蒙古医学院学报》1999年第1期61-65,共5页Acta Academiae Medicinae Neimongol

摘　　要：胃癌的发生可分为正常粘膜转化为慢性萎缩性胃炎及肠化生的癌前病变和癌前病变转化为胃癌二个阶段。Ｎ－亚硝酰胺（ＮＡＤ）在这二个阶段均起作用。由于ＮＡＤ的不稳定性，从饮食直接摄入的可能性很小，而其前体物ＮＯ－３、ＮＯ－２及酰胺在饮食中广泛存在；胃内合成是唯一的途径。当胃腺萎缩消失，胃内ｐＨ升高，ｐＨ＞５，细菌大量繁殖，参与催化ＮＡＤ的合成。The production of gastric cancer has two stage,one of them is normal mucous membrane changing to chronic atrophic gastritis and pre-canceration of intestinal metaplasia ,another pre-canceration changing to gastric cancer.Becouse dissteady of NAD,it is little possibility direct from food.NAD precursors (NO - 3,NO - 2,AD)are extensively in food.Synthetize of NAD is only way in the stomach.When gastric gland appear atrophy and disappear,bacteria have high amount reproduction in pH>5,and it catalyze synthesis of NAD.

关 键 词：N-亚硝酰胺 胃癌 细菌 合成 

分 类 号：R735.202[医药卫生—肿瘤]