葱白多糖的降血脂功能及对酒精肝预防作用的研究  

Study on Reducing Blood Lipid and Prevention of Alcohol Liver of Fistular Onion Stalk(Allium schoenoprasum L.) Polysaccharides

作　　者：张英[1,2] 石雪萍[1] 姜洪芳[1] 张卫明[1] 金敬宏[1] 

机构地区：[1]南京野生植物综合利用研究院,江苏南京210042 [2]南京农业大学食品科技学院,江苏南京210095

出　　处：《食品与生物技术学报》2010年第4期521-525,共5页Journal of Food Science and Biotechnology

基　　金：国家"十一五"科技支撑计划重点项目(2006BAD06B02);科技部农业科技成果转化项目(2007GB24420251)

摘　　要：研究了葱白多糖对大鼠血脂水平的影响以及对小鼠脂肪肝的预防作用。在研究多糖的降血脂功能试验中,设对照组和葱白多糖低、中、高剂量组,分别为100、200、400 mg/kg(以体重计),连续给大鼠灌胃30 d后取尾血,测定血清TC、TG和HDL-C的含量。结果表明:多糖降血脂效果优于血脂康,且高剂量组降血脂效果优于低剂量组;高剂量组对大鼠TG降低显著、对TC降低不显著;各剂量组均对HDL-C升高显著。在研究多糖对小鼠酒精肝预防作用的试验中,设对照组和葱白多糖低、中、高剂量组(剂量同上),连续给小鼠灌胃30 d后,测定肝脏MDA、血清TG和GSH的含量。结果表明:多糖对酒精肝预防作用较水飞蓟素弱;高剂量组对TG降低显著、对GSH升高显著;各剂量组均对MDA降低显著。由此看来,葱白多糖对大鼠有降血脂功能,对小鼠的酒精肝预防作用较弱。This manuscript studied the effects of the polysacchrides from Fistular Onion Stalk on blood lipid and their preventive effects on alcoholic liver.In the function test of reducing blood lipid,the wistar rats were divided into six groups： three control groups,low dose group（100 mg/kg）,middle dose group（200 mg/kg）,high dose group（400 mg/kg）.After continuously feeding to rats for 30 days,we take tail blood to determine the content of TC,TG and HDL-C.The results showed that the effect of reducing blood lipid of polysaccharides was better than Xuezhikang capsule.The high dose group significantly reduce TG but not TC.Every dose group could increase HDL-C significantly.In the test of the preventive effect of alcoholic liver,the mice were divided into six groups as the aboved.Continuously feeding to mice for 30 days,we determine the content of MDA,TG and GSH.The results showed that the preventive effect of of polysaccharides on alcoholic liver was worse than Shuifeilisu;The high dose group can significantly reduce TG but increase GSH content.Every group could reduce MDA significantly.From these results we drew the conclusion that Fistular Onion Stalk Polysaccharides could reduce blood lipid of wistar rats but the preventive effect on alcoholic liver was weak.

关 键 词：葱白多糖 动物实验 降血脂 酒精肝预防作用 

分 类 号：R285.5[医药卫生—中药学]