重症肌无力胸腺摘除前后血清抗乙酰胆碱受体抗体、抗突触前膜抗体及可溶性白细胞介素_2受体的变化  

Serum AchRab, PrM and sIL-2R in patients with myasthenia Gravis before and after thymectomy

作　　者：张清勇[1] 魏云[1] 王铁栓[1] 杜英[2] 张斌[1] 王宪忠 

机构地区：[1]河南医科大学第二附属医院胸外科,郑州450003 [2]河南医科大学微生物学与免疫学教研室 [3]河南省永城县人民医院

出　　处：《中华实验外科杂志》1999年第3期220-221,共2页Chinese Journal of Experimental Surgery

基　　金：河南省自然科学基金!964021500

摘　　要：目的探讨胸腺摘除对重症肌无力患者血清抗乙酸胆感受体抗体、抗灾触前膜抗体（AchRab）、（PrM））和可溶性白细胞介素2受体（sIL－2R）水平的影响。方法采取39例重症肌无力（myastheniagravis，MG）患者在胸腺摘除前后和40例健康献血员血清，用ELISA法检出AchRab、PrM及sIL－2R的水平。结果64．2％的重症肌无力患者血清AchRab显著增高，27．5％的重症肌无力患者PsmRab显著增高，AchRab和PrM同时增高者占15％。重症肌无力患者血清sIL-2R显著高于正常者占79.6％。三项指标在胸腺摘除后有显著下降的比例分别为48％、45％、32％。结论胸腺摘除对外周血中的AchRab、PrM、sIL-2R有明显下调作用。Objective To investigate the changes in serum AchRab, PrM, sIL-2R in patients withmyasthenia Gravis (MG) before and after thymectomy. Method Serum AchRab. PrM, and sIb-2R in MGpatients were determined with ELISA. Results The positive rate of AchRab and PrM in MG patients was64. 2 % and 27. 5 % respectively. The peitive rate of both AchRab and PrM in MG patients was 15 %. SerumsIL-2R level of 79. 6% MG patients was obviously increased as compared with that of normal subjects. Afterthymectomy, the titers of AchRab, PrM and sIL-2R were markedly decreased with the ratio beng 48%,45% and 32% respectively. Conclusion Thyrnectomy could induce the down-regulation of serum AchRab,PrM and sIL-2R.

关 键 词：重症肌无力 胸腺摘除 ACHRAB PRM SIL-2R 

分 类 号：R746.102[医药卫生—神经病学与精神病学]