儿童急性白血病的有效化学治疗  

EFFCTIVE CHEMOTHERAPY OF ACUTE LEUKEMIA IN CHILDREN

作　　者：殷慧君[1] 陆爱东[1] 刘桂兰[1] 张乐萍[1] 商晓云 杨志敏[1] 李虹[1] 田开功 

机构地区：[1]北京医科大学人民医院儿科

出　　处：《中国癌症杂志》1999年第2期132-134,共3页China Oncology

摘　　要：目的总结了我院初治１１５例急性淋巴细胞白血病（ＡＬＬ）及３０例急性髓性白血病（ＡＭＬ）的诱导缓解治疗效果，同时介绍了早期巩固强化治疗方案。方法ＡＬＬ诱导化疗方案：病人共分三组：（１）ＣＯＰ，（２）ＣＯＰ＋ＤＮＲ，（３）ＣＯＰ＋ＩＤＡ。以第８天骨髓象＜５％为良好快速早期反应（ｒａｐｉｄｅａｒｌｙｒｅｓｐｏｎｓｅ，ＲＥＲ）的标准。ＡＭＬ诱导缓解治疗方案为ＡＤ＋ＶＰ１６。结果三组ＲＥＲ良好的百分率分别为：６８３％，７５７％，９０９％。第一组与第三组之间Ｐ＜００５，疗效存在显著性差异。ＡＭＬ一个疗程达到完全缓解的占９０％。结论可供分析无病生存期的ＡＬＬ病例共６０例，无病生存达４年以上者占８５％（５１／６０）。ＡＭＬ共３０例，无病生存达４年以上者占７０％（２１／３０）。PURPOSE In an effort to introduce on our experience induction chemotherapy and consolidation and intensification therapy in children with acute lymphoblastic leukemia and acute myeloid leukemia.METHODS 115 newly diagnosed patients with ALL and 30 newly diagnosed patients with AML were enrolled in this study.Patients with ALL were divided into three groups:(1)COP,(2)COP add DNR,(3)COP add IDA.They received day 8 bone marrow aspirate to evaluate rapid early response(RER).We designated absolute blast index aspirate(ABI aspirate) of <0 05 as a good RER.Patients with AML received AD+VP16 as induction therapy. RESULTS The good RER rate of the three ALL groups were (1) 68.3%,(2)75.7%,(3)90.9% respectively.The group(3) was significantly better than group (1)( P <0.05).The complete remission rate of AML was 90% after one course of chemotherapy.CONCLUSIONS Of the 60 patients with ALL who had been followed up,51(85%) got 4 years DFS. Of the 30 patients with AML,21(70%) got 4 year DFS.

关 键 词：急性白血病 早期反应 无病生存率 药物疗法 儿童 

分 类 号：R733.710.5[医药卫生—肿瘤] R730.53[医药卫生—临床医学]