壳聚糖纳米粒和微球体外结合脂类和胆酸盐的研究  

Study on the effects of chitosan nanoparticles and microspheres on binding capacities of lipids and bile salts in vitro

作　　者：陶毅[1] 邬思辉 张宏亮[1] 张文燕[3] 陈弘淳[3] 苏政权[3] 

机构地区：[1]广东药学院药科学院,广州510006 [2]广东省食品药品职业技术学校,广州510663 [3]广东药学院公共卫生学院,广州510240

出　　处：《食品科技》2010年第9期271-274,279,共5页Food Science and Technology

基　　金：广东省科技计划项目(2009B020313006);中山市科技计划项目(2009H017)

摘　　要：通过离子交联法和喷雾干燥法分别制备了壳聚糖纳米粒和壳聚糖微球,在体外模拟人体消化系统环境考察壳聚糖纳米粒和微球对脂类和胆酸盐的结合能力。实验结果表明:壳聚糖纳米粒和微球粒径范围分别为200～800 nm和5～8μm;壳聚糖纳米粒和微球对脂类和胆酸盐的结合能力显著高于普通壳聚糖;并且,粒子粒径越小结合能力越强。Preparation of chitosan nanoparticles and microspheres by ionic gelation process and spray-drying methods and investigation of the effects of chitosan nanoparticles and microspheres on binding capacities of lipids and bile salts in the conditions simulating human gastrointestinal tract in vitro.The results indicated that the mean particles size of chitoan nanoparticles and microspheres varied from 200～800 nm and from 5～8 μm,respectively.The binding capacities of lipids and bile salts of chitosan nanoparticles and microspheres were more effective compared with chiosan.And the smaller the particle size was,the more effective the binding capacity of lipids and bile salts was.

关 键 词：壳聚糖 纳米粒 微球 脂类 胆酸盐 

分 类 号：TS202.3[轻工技术与工程—食品科学]