蛋白S基因突变致静脉血栓的研究进展  

Progress of Research in Protein S Mutation Induced Deep Venous Thromboembolism

作　　者：于丽侠[1] 杨晓红[2] 

机构地区：[1]新疆医科大学研究生院,乌鲁木齐830000 [2]新疆维吾尔自治区人民医院呼吸一科,乌鲁木齐830000

出　　处：《医学综述》2010年第18期2746-2748,共3页Medical Recapitulate

摘　　要：蛋白S是抗凝血过程中重要的辅因子,它可加速活化蛋白C灭活因子Ⅴa、Ⅷa。丝氨酸460被脯氨酸替代是蛋白S缺陷最普遍的原因,蛋白S基因缺陷可导致血栓形成的危险性明显增加。现对蛋白S的结构和生物学功能,遗传性蛋白S缺陷症的分子发病机制、分型、诊断及其与静脉血栓的关系予以综述。Protein S（PS）is a co-factor of anti-coagulation,which can accelerate the degradation of factor Ⅴa and Ⅷa with APC.The defect of protein S increases the risk of thrombosis.The decrease of PS activation weakens the anticoagulation of PC system,therefore increasing the risk of thromboembolism.This article reviews the structure,biological function of PS,the molecular pathogenesis of congenital PS deficiency,genotypes,diagnosis,and the relationship with venous thromboembolism.

关 键 词：蛋白S 基因突变 静脉血栓 

分 类 号：R364.15[医药卫生—病理学]