多种营养素联合应用对儿童铅中毒影响  

Joint effects of nutrients on lead poisoning in children

作　　者：宋柏捷[1] 杨艳晖[1] 焦广宇[1] 

机构地区：[1]哈尔滨医科大学附属第二医院临床营养教研室,黑龙江哈尔滨150086

出　　处：《中国公共卫生》2010年第10期1263-1264,共2页Chinese Journal of Public Health

基　　金：黑龙江省卫生厅科研课题(2007-365)

摘　　要：目的探讨多种营养素联合应用对铅毒性的拮抗作用。方法采用自身对照及组间对照法,对维生素C、维生素B1及钙、铁、锌、硒6种已知对铅毒性有拮抗作用的营养素进行人体干预研究。结果试验组血铅平均值由(160.4±29.2)μg/L下降为(125.8±20.1)μg/L;尿铅平均值由(30.4±8.5)μg/L增加为(39.6±11.6)μg/L;与试食前和对照组比较,试食组试食后血铅下降及尿铅排出差异均有统计学意义(P<0.01);试食组相同时间点尿铅排出率高于尿钙、尿锌的排出率(P<0.05),且临床症状有较明显改善(P<0.05)。结论多种营养素联合应用具有拮抗儿童铅中毒的作用。Objective To explore the joint effects of nutrients against the toxicity of lead.Methods With self-comparison and group-comparison design,six nutrients were tested in a clinical intervention trial.The nutrients were vitamin C,vitamin B1,calcium,iron,zinc,selenium,which have effects of against lead toxicity.Results On the avrage,the nutrients could reduce blood lead from 160.4±29.2 μg/L to 125.8±20.1 μg/L and increase urine lead from 30.4±8.5 μg/L to 39.6±11.6 μg/L in the experimental group.After the experiment,the experimental group showed significant differences compared with itself and the control group in the descent of blood lead and the elimination of urine lead（P0.01）.The elimination ratio of urine lead was higher than that of urine calcium and urine zinc in the experimental group on the same time point（P0.05）.The nutrients relieved clinical symptoms of the patients（P0.05）.Conclusion The joint effects of nutrients against lead poisoning could be achieved by joint administration in children.

关 键 词：营养素 铅中毒 拮抗作用 

分 类 号：R151.43[医药卫生—营养与食品卫生学]