两种基本味觉的口腔感知对味觉中枢激活情况的探索  

Human brain gustatory area activation inducted by sweet and salty taste studied with fMRI

作　　者：刘雪梅[1] 贾静[2] 刘洪臣[3] 金真[4] 李科[4] 

机构地区：[1]解放军总医院口腔修复科,主治医师北京100853 [2]武警总医院口腔科,副主任医师北京100039 [3]解放军总医院口腔医学研究所,主任主任医师教授北京100853 [4]解放军第三零六医院核磁共振室,主任医师北京100101

出　　处：《口腔颌面修复学杂志》2010年第3期147-150,共4页Chinese Journal of Prosthodontics

基　　金：国家自然科学基金(项目编号:30772450);北京市自然科学基金项目(项目编号:7082086)

摘　　要：目的:应用脑磁共振功能成像技术对比研究口腔甜味觉及咸味觉感知对大脑初级味觉中枢和二级味觉中枢的激活情况。方法:对11例正常受试者,依照事件相关设计,给予甜味、咸味及无味对照的味觉刺激,采集全脑血氧水平依赖对比的fMRI扫描数据。用SPM99软件包进行t检验统计分析,以获取甜味刺激、咸味刺激与无味对照刺激对比的脑功能图像。结果:两种味觉均在双侧脑岛及岛盖等区引起激活。左侧前额皮质仅被甜味觉激活。两者激活最强的脑区均在右侧脑岛及岛盖。结论:基本味觉中的甜味觉及咸味觉在初级味觉中枢和二级味觉中枢的激活情况存在差异。Objective：To investigate human brain gustatory area activation inducted by sweet and salty taste usingfunctional MRI.Methods：fMRI-BOLD scan covering the whole brain was performed on 11 healthy human subjects during event-relate designed stimulation with sweet taste,salty taste and tasteless control.The fMRI data was analyzed by SPM99 software with statistic t-test to generate the activation map.Result：Activations induced by both sweet and salty stimuli were found in bilateral insula and operculum,right prefrontal cortex was found only activated by sweet stimulus,whereas strongest signal was found in right insula and operculum by both stimuli.Conclusion：Cortical representation of sweet and salty taste was not similar.Differences exist in primary and secondary gustatory area among the two taste.

关 键 词：初级味觉中枢 二级味觉中枢 味觉 功能磁共振成像 

分 类 号：R78[医药卫生—口腔医学]