Molecular basis of the first cell fate determination in mouse embryogenesis  

作　　者：Lingyi Chen Dekun Wang Zhaoting Wu Liping Ma George Q Daley 

机构地区：[1]Ministry of Education Key Laboratory of Bioactive Materials, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China [2]Division of Pediatric Hematology/Oncology, Children's Hospital Boston and Dana Farber Cancer Institute, 300 Longwood Avenue, Boston, MA 02115, USA [3]Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School Boston, MA, USA [4]Division of Hematology, Brigham and Women's Hospital Boston, MA, USA [5]Harvard Stem Cell Institute, Boston, MA, USA [6]Howard Hughes Medical Institute, Boston, MA, USA

出　　处：《Cell Research》2010年第9期982-993,共12页细胞研究（英文版）

摘　　要：Through proliferation and differentiation, a single cell, the zygote, can give rise to a complex organism composed of many types of cells. Up to the eight-cell embryo stage, the blastomeres are morphologically identical and distributed symmetrically in the mammalian embryo. Functionally, in some species, they are all totipotent. However, due to the compaction of blastomeres and the asymmetrical cell division at the late phase of the eight-cell embryo, the blastomeres of the morula are no longer identical. During the transition from morula to blastocyst, blastomeres differentiate, resulting in the first cell fate decision in embryogenesis, namely, the segregation of the inner cell mass and the tropheetoderm. In this review, we will discuss the regulatory mechanisms essential for the cell fate choice during blastocyst development, including transcriptional regulation, epigenetic regulation, mieroRNAs, and signal transduction.

关 键 词：inner cell mass TROPHECTODERM EMBRYOGENESIS 

分 类 号：Q954.4[生物学—动物学] S852.65[农业科学—基础兽医学]