天然虾青素缓解体力疲劳作用的实验研究  

Alleviative effect of natural astaxanthin on physical fatigue

作　　者：陈东方[1] 王海玉[1] 李立[1] 张聪恪[1] 刘翠娥[1] 

机构地区：[1]河南省疾病预防控制中心,河南郑州450016

出　　处：《中国现代医学杂志》2010年第17期2567-2569,共3页China Journal of Modern Medicine

摘　　要：目的研究天然虾青素缓解体力疲劳的作用。方法雄性昆明小鼠192只,体重18～22g,按体重随机分成对照组和100、200和600mg/kg3个剂量组,每组48只。小鼠经口灌胃给予天然虾青素30天后,分别测定负重游泳时间、血清尿素氮、血乳酸及肝糖原含量。结果 200mg/kg和600mg/kg剂量组天然虾青素小鼠负重游泳时间显著长于对照组,小鼠游泳前后血乳酸测定曲线下的面积显著低于对照组,血清尿素氮含量低于对照组,小鼠肝糖原水平明显高于对照组。结论天然虾青素具有缓解体力疲劳的作用。ObjectiveTo explore the alleviative effect of natural astaxanthin on physical fatigue.Methods Totally 192 male KM mice weighing 18～22 g were equally divided into four groups：soybean oil control group and three experimental groups in which the doses of astaxanthin were 100,200 and 600 mg/kg bw respectively.After oral administration for 30 days,loaded swimming time,blood lactic acid,serum urea nitrogen and glycogen in liver were determined.ResultsThe loaded swimming time of mice in the group of 200 mg/kg bw and 600 mg/kg bw was significantly longer than that in the group of soybean oil control group（P 0.05）.The areas under the blood lactic acid curve of before,0 minute and 20 minutes after swimming in the groups of 200 mg/kg bw and 600mg/kg bw were significantly smaller than those in soybean oil control group（P 0.05）.In the groups of 200 mg/kg bw and 600mg/kg bw astaxanthin,serum urea nitrogen level after swimming was obviously decreased,while the content of liver glycogen was significantly more than that in the group of soybean oil control group（P 0.05）.Conclusion Natural astaxanthin can alleviate physical fatigue in mice.

关 键 词：虾青素 体力疲劳 负重游泳 

分 类 号：R-332[医药卫生]