巴斯德毕赤酵母GS115基因组研究进展  

Advances in the genome of pichia pastoris GS115

作　　者：王永刚[1] 马雪青[1] 王倩[1] 周贤婧[1] 赵虎彪[1] 马建忠[1] 

机构地区：[1]兰州理工大学生命科学与工程学院,甘肃兰州730050

出　　处：《食品工业科技》2010年第11期379-381,385,共4页Science and Technology of Food Industry

基　　金：兰州理工大学学生科技创新基金项目;兰州市科技局项目(07-02-44)

摘　　要：毕赤酵母生物表达系统已成功地表达了多种重组外源活性蛋白,广泛地被应用于能源、医疗、科学研究等方面的研究。综述了2008年以来毕赤酵母GS115基因组研究,以期从分子水平解释转录调控、表达调控及翻译后修饰等机理,进而解决毕赤酵母发酵过程中产量低、过糖基化等瓶颈。The Pichia pastoris expression system has been used successfully for the production of the bioactivity of various recombinant heterologous proteins.The recent genome developments with respect to the Pichia pastoris GS115 were reviewed.From the molecular level, the transcriptional regulation, expression regulation mechanism, post-translational modification and other mechanisms were explained.It was aim to solve the low yield of the aimed fermentation production,over-glycosylation and other bottlenecks.

关 键 词：毕赤酵母GS115 基因组 进展 

分 类 号：TS201.3[轻工技术与工程—食品科学]