秦皮水煎剂对SD大鼠胚胎/胎儿发育的影响  

Effects of Cortex Fraxini Decoction on Embryo-Fetal Development in Rats

作　　者：张旻[1] 刘晓萌[1] 宋捷[1] 胡燕萍[1] 王秀文[1] 李波[1] 

机构地区：[1]中国药品生物制品检定所国家药物安全评价监测中心,北京100175

出　　处：《世界科学技术-中医药现代化》2010年第5期788-792,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科学技术部国际科技合作项目(2006DFB31690):促进中药材在法国的注册和进入;负责人:林瑞超

摘　　要：目的:观察秦皮水煎剂对SD大鼠胚胎/胎儿发育的影响。方法:采用SD孕鼠,分为溶媒对照组、秦皮组,每组20只交配成功动物,于妊娠第6日开始至妊娠第17日经口灌胃给予秦皮水煎剂27.3g(生药)·kg^(-1),每天1次,于妊娠第20天解剖。观察母体动物的临床症状、体重变化、摄食量、母体动物的黄体数、着床数、胚胎生存死亡情况、生存胎仔的性别、体重、外观、骨骼及内脏检查等指标;结果:秦皮组于妊娠第6～12d引起SD妊娠大鼠摄食量显著降低,停药后,摄食量显著增加,雄性与雌性胎儿体重较对照组明显增高,其余母体及胚胎/胎儿发育各项指标未见明显影响。结论:在本实验条件下,秦皮水煎剂未见明显的母体毒性与胚胎/胎儿发育毒性。The potential for Cortex Fraxini decoction to induce developmental toxicity was investigated in SD rats. Timed-pregnant SD rats （20 rats/group） were given Cortex Fraxini decoction （27.3g （herbal raw material）/kg/day） or Vehicles i distilled water） by gavage on gestation days 6 through 17. Maternal clinical sign, abortions, premature deliveries, and body weight were monitored throughout gestation. At termination （gestation days 20） pregnant females were evaluated for clinical status and gestational outcome; live fetuses were examined for gender, external, visceral and skeletal malformation and variations. No deaths, premature deliveries or dose-related clinical signs were attribut- ed to Cortex Fraxini decoction. Maternal body weight and body weight gain were not affected. Food consumption was significantly decreased from GD6 to GD12 and increased from GD18 to GD 20. Fetal weights were statistically increased. There were no effects observed on fetus viability, incidences of fetal malformation and variation. These results demonstrate that Cortex Fraxini decoction has no detectable adverse effects on either the treated F0 female rats or the fetuses.

关 键 词：秦皮 发育毒性 

分 类 号：R714.51[医药卫生—妇产科学]