异甘草素微胶囊的制备及释放性的研究  

Preparation of Isoliquiritigenin Microcapsule and their Release in Vitro

作　　者：周锦霞[1] 伍林[1] 王建国[1,2] 

机构地区：[1]武汉科技大学应用化学研究所,湖北武汉430081 [2]九江学院化学化工学院,江西九江332005

出　　处：《现代食品科技》2010年第10期1132-1135,1159,共5页Modern Food Science and Technology

摘　　要：本文以微胶囊的包埋率和载药量为考察对象,采用内源乳化法制备了异甘草素微胶囊并对其体外释药性进行了研究。其最佳制备条件为:海藻酸钠的浓度为2%,搅拌速度为600r/min;Span80与Tween80的质量比为2.5:1;异甘草素的加入量为30mg。得到微胶囊形态完好,表面光滑;平均包封率和载药量分别为64.5%和4.24%。并在通过模拟肠液和模拟胃液中的释放曲线推测了其释放机理。In this paper,isoliquiritigenin microcapsules were prepared and its release in vitro was also studied.The optimized conditions for the preparation of isoliquiritigenin microcapsules were sodium alginate concentration of 2%,stirring speed of 600r/min,the mass ratio of Span80 to Tween80 of 2.5：1 and isoliquiritigenin dosage of 30 mg.Under these conditions,the microcapsules had good shape and smooth surface,with the average encapsulation efficiency and drug loading being of 64.5% and 4.24%,respectively.And the release curves were made in simulated intestinal fluid and simulated gastric juice.

关 键 词：异甘草素 微胶囊 体外释药性 

分 类 号：TQ461[化学工程—制药化工]