中、晚孕期超声筛查13-三体的临床价值  

Clinical value of ultrasonography in screening trisomy 13 during the second and third trimesters of gestation

作　　者：潘玉萍[1] 蔡爱露[1] 解丽梅[1] 王晓光[1] 王冰[1] 关洪波[2] 乔宠[2] 王丽芝[2] 王岳平[3] 刘雨函[1] 赵一理[1] 

机构地区：[1]中国医科大学附属盛京医院超声科,辽宁沈阳110004 [2]中国医科大学附属盛京医院妇产科,辽宁沈阳110004 [3]中国医科大学附属盛京医院遗传室,辽宁沈阳110004

出　　处：《中国医学影像技术》2010年第11期2134-2136,共3页Chinese Journal of Medical Imaging Technology

基　　金：国家科技支撑计划(2006BAI05A04)

摘　　要：目的探讨中、晚孕期超声筛查13-三体的临床价值。方法对妊娠中期和中晚期有产前诊断指征的3297名孕妇行羊膜腔穿刺术和脐带穿刺术检查染色体核型,比较不同指征孕妇的13-三体检出率,并分析13-三体与超声表现异常的关系。结果接受羊膜腔穿刺术和脐带穿刺术的3297名孕妇中,检出13-三体3胎,检出率为0.09%。3297名孕妇中单纯超声表现异常226名,检出13-三体2胎,检出率为0.88%。单纯超声表现异常的13-三体检出率(0.88%)明显高于唐氏综合征高危指征(P=0.001)。结论中、晚孕期超声筛查有助于检出13-三体胎儿,具有重要临床价值。Objective To investigate the clinical value of ultrasonography in screening trisomy 13 during the second and third trimesters.Methods Amniocentesis and cordocentesis were performed on 3297 pregnant women with indications for prenatal diagnosis to detect karyotype of the fetus during second trimester and late pregnancy.The detection rates of trisomy 13 were compared among different indications of pregnant women.The relationship between the ultrasonography abnormalities and trisomy 13 was analyzed.Results In chromosomal karyotypes analysis of 3297 pregnant women by amniocentesis and cordocentesis,3 trisomy 13 were detected with a detection rate of 0.09%.There were 226 in 3297 pregnant women with simple ultrasonography abnormalities,and 2 of them were found with trisomy 13 with a detection rate of 0.88%.The detection rate of trisomy 13 detected with ultrasound（0.88%）was higher than that with the Down＇s syndrome high risk（P=0.001）.Conclusion During the second and third trimester,ultrasonography contributes to detect the trisomy.

关 键 词：羊膜腔穿刺术 脐带穿刺术 核型分析 超声检查 产前 三体性 

分 类 号：R445.1[医药卫生—影像医学与核医学] R714.53[医药卫生—诊断学]